Product Information:

NUBIGET 10mg Injection contains Nubain (Nalbuphine Hydrochloride) 10mg/mL, a synthetic opioid agonist-antagonist analgesic. Nalbuphine acts primarily as a kappa-opioid receptor agonist and mu-opioid receptor partial antagonist, providing effective pain relief with a lower risk of respiratory depression and dependence compared to full mu-agonists like morphine.

It is used for moderate to severe acute pain in hospital or clinical settings.

⚠️ Note: In Pakistan, "NUBIGET" is commonly recognized as the brand name for nalbuphine injection. Always confirm the active ingredient on the label.

Uses of (NUBIGET 10MG INJECTION):

1. Management of moderate to severe acute pain (e.g., postoperative, trauma, renal colic)
2. Obstetric analgesia during labor (does not significantly depress neonatal respiration at therapeutic doses)
3. Balanced anesthesia as an adjunct during surgery
4. Alternative to morphine in patients at risk of respiratory depression

Key Benefits of (NUBIGET 10MG INJECTION):

1. Effective analgesia with ceiling effect on respiratory depression (safer than morphine in overdose)
2. Lower potential for physical dependence and abuse
3. Does not cause significant histamine release (less hypotension/flushing)
4. Suitable for use in labor and delivery

How To Use (NUBIGET 10MG INJECTION):

1. Administered by a healthcare professional via intravenous (IV), intramuscular (IM), or subcutaneous (SC) route.
2. Typical adult dose:
3. IV: 5–10mg every 3–6 hours
4. IM/SC: 10mg every 3–6 hours
5. Maximum single dose: 20mg
6. Maximum daily dose: 160mg
7. Onset: 2–3 minutes (IV), 15 minutes (IM); Duration: 3–6 hours

When Not to Use (NUBIGET 10MG INJECTION):

Do not use if you have:

1. Significant respiratory depression
2. Acute or severe bronchial asthma (in unmonitored setting)
3. Known hypersensitivity to nalbuphine
4. Concomitant use of full mu-opioid agonists (may precipitate withdrawal)

Side Effects of (NUBIGET 10MG INJECTION):

Common: Sedation, dizziness, nausea, vomiting, sweating, dry mouth.

Less common: Vertigo, headache, euphoria/dysphoria.

Serious (rare):

1. Respiratory depression (less than morphine, but possible at high doses)
2. Hypotension or hypertension
3. Physical dependence (with prolonged use)
4. Opioid withdrawal symptoms if given to opioid-dependent patients
5. Discontinue and monitor if CNS or respiratory depression occurs.

Dosage: (NUBIGET 10MG INJECTION):

1. Adults: 10mg IM/IV every 3–6 hours as needed
2. Elderly or debilitated: Start with 5mg; titrate slowly
3. Renal/hepatic impairment: Use reduced doses
4. Obstetrics: 10–20mg IM/IV during labor (avoid close to delivery unless benefit outweighs risk)

Who It’s For (NUBIGET 10MG INJECTION):

Hospitalized adults requiring short-term management of moderate to severe acute pain, especially when morphine-like opioids are contraindicated or pose higher risk.

Warnings & Precautions:

1. Use with caution in head injury (may interfere with neurological assessment)
2. Avoid in undiagnosed abdominal pain (may mask symptoms)
3. Monitor for sedation and respiratory rate, especially with first dose
4. May impair ability to drive or operate machinery

Drug Interactions:

1. CNS depressants (benzodiazepines, alcohol, barbiturates): ↑ Risk of sedation/respiratory depression
2. Full opioid agonists (morphine, fentanyl): May reduce analgesic effect or cause withdrawal
3. MAO inhibitors: Potential for serotonin syndrome (theoretical)
4. Always inform your doctor about all medications.

Additional Information:

Store below 25°C, protected from light. Keep out of reach of children. For hospital or clinical use only. Available by prescription in Pakistan.