Product Information:

NIMIXA 550mg Tablets contain a fixed-dose combination of:

1. Nimesulide 100mg – a selective COX-2 inhibitor NSAID for pain and inflammation
2. Paracetamol (Acetaminophen) 450mg – an analgesic and antipyretic that acts centrally

This combination leverages dual mechanisms to provide enhanced pain relief, particularly for moderate to severe acute pain, while aiming to reduce the required dose of each component.

⚠️ Critical Safety Note:

1. Nimesulide carries a risk of severe hepatotoxicity (liver damage) and is restricted to short-term use (≤7–10 days) in adults.
2. Banned in many countries (EU, USA, Canada); in Pakistan, it is only permitted for adults ≥12 years under strict medical supervision.
3. Do not exceed recommended dose or duration.

Uses of (NIMIXA 550MG TABLETS):

1. Acute moderate to severe pain (e.g., dental pain, postoperative pain, musculoskeletal injury)
2. Painful osteoarthritis or rheumatoid arthritis flare-ups
3. Primary dysmenorrhea (painful menstruation)
4. Fever with associated pain

Key Benefits of (NIMIXA 550MG TABLETS):

1. Synergistic analgesic effect from dual action
2. Faster and more effective pain relief than either drug alone
3. Lower individual doses may reduce side effects (though nimesulide risk remains)

How To Use (NIMIXA 550MG TABLETS):

1. Take one tablet every 12 hours (max 2 tablets/day), after meals to reduce gastric irritation.
2. Swallow whole with water—do not crush or chew.
3. Maximum duration: Not more than 7–10 days
4. Avoid alcohol during treatment.

When Not to Use (NIMIXA 550MG TABLETS):

Do not use if you have:

1. Active peptic ulcer or GI bleeding
2. History of drug-induced liver injury (especially nimesulide)
3. Severe hepatic or renal impairment
4. Hypersensitivity to nimesulide, paracetamol, or other NSAIDs
5. Children <12 years
6. Pregnancy (especially third trimester) or breastfeeding
7. Chronic alcohol use

Side Effects of (NIMIXA 550MG TABLETS):

Common: Nausea, heartburn, dizziness, headache, mild abdominal discomfort.

Rare: Skin rash, elevated liver enzymes, fluid retention.

Serious (discontinue immediately):

1. Hepatotoxicity: Jaundice, dark urine, fatigue, right upper quadrant pain
2. GI bleeding: Black stools, vomiting blood
3. Severe skin reactions: Stevens-Johnson syndrome
4. Paracetamol toxicity (if overdosed): Nausea, vomiting, liver failure
5. Seek emergency care if signs of liver injury or allergic reaction occur.

Dosage: (NIMIXA 550MG TABLETS):

1. Adults: 1 tablet (100mg nimesulide + 450mg paracetamol) every 12 hours
2. Maximum daily dose: 2 tablets (200mg nimesulide + 900mg paracetamol)
3. Duration: ≤7–10 days only
4. Elderly: Use lowest effective dose; monitor liver/kidney function

Who It’s For (NIMIXA 550MG TABLETS):

Adults (≥12 years) with acute, moderate to severe pain requiring stronger relief than paracetamol alone—only when safer alternatives are inadequate.

Warnings & Precautions:

1. Monitor liver function if used beyond 5 days
2. Never combine with other paracetamol or NSAID-containing products (risk of overdose)
3. Avoid alcohol—increases risk of liver damage from both components
4. Discontinue at first sign of jaundice, nausea, or fatigue
5. Not for chronic pain management

Drug Interactions:

1. Warfarin: ↑ Bleeding risk (nimesulide + paracetamol)
2. Lithium, methotrexate: ↑ Toxicity (nimesulide)
3. Antihypertensives: Reduced efficacy + renal risk
4. Alcohol: ↑ Hepatotoxicity
5. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use beyond 10 days. Available by prescription in Pakistan.