Product Information:

NEBIL 2.5mg Tablets contain Nebivolol 2.5mg, a highly selective beta-1 adrenergic receptor blocker with unique vasodilatory properties mediated through nitric oxide (NO) release. Unlike conventional beta-blockers, nebivolol reduces blood pressure while preserving or even improving peripheral blood flow and does not cause significant bradycardia at lower doses.

This low-strength formulation is ideal for initiating therapy, use in elderly patients, or those with comorbidities requiring gentle blood pressure control.

Uses of (NEBIL 2.5MG TABLETS):

1. First-line or add-on treatment of essential hypertension
2. Management of chronic stable heart failure (as adjunct therapy in select patients)
3. Off-label: Migraine prophylaxis, essential tremor

Key Benefits of (NEBIL 2.5MG TABLETS):

1. Dual action: Beta-blockade + vasodilation = effective BP lowering with fewer side effects
2. Cardioselective—minimal impact on bronchial smooth muscle (safer in mild COPD)
3. Improves endothelial function and arterial stiffness
4. Once-daily dosing for consistent 24-hour control
5. Well-tolerated starting dose for sensitive individuals

How To Use (NEBIL 2.5MG TABLETS):

1. Take one tablet once daily, preferably in the morning, at the same time each day.
2. Swallow whole with water—can be taken with or without food.
3. Do not stop abruptly—taper gradually under medical supervision to avoid rebound hypertension or angina.
4. Full antihypertensive effect may take 1–2 weeks.

When Not to Use (NEBIL 2.5MG TABLETS):

Do not use if you have:

1. Acute or decompensated heart failure
2. Sick sinus syndrome or 2nd/3rd-degree AV block (unless paced)
3. Resting heart rate <50 bpm
4. Cardiogenic shock or severe hypotension
5. Severe hepatic impairment
6. Hypersensitivity to nebivolol

Side Effects of (NEBIL 2.5MG TABLETS):

Common: Mild headache, fatigue, dizziness, nausea.

Rare: Cold extremities (less than other beta-blockers), sleep disturbances, erectile dysfunction.

Serious (rare):

1. Worsening heart failure (in unstable patients)
2. Bronchospasm (use cautiously in asthma/COPD)
3. Symptomatic bradycardia or hypotension
4. Discontinue and seek medical help if shortness of breath, fainting, or chest pain occurs.

Dosage: (NEBIL 2.5MG TABLETS):

1. Hypertension (starting dose): 2.5–5mg once daily
2. Elderly or frail patients: Start at 2.5mg once daily
3. Heart failure: Initial dose 1.25mg; 2.5mg may be used in stable patients
4. Maximum dose: Up to 10mg once daily (titrated gradually)

Who It’s For (NEBIL 2.5MG TABLETS):

1. Elderly patients initiating antihypertensive therapy
2. Adults with mild hypertension or high sensitivity to beta-blockers
3. Patients with concomitant conditions requiring gentle hemodynamic control

Warnings & Precautions:

1. Avoid abrupt discontinuation—risk of rebound hypertension or myocardial ischemia
2. May mask tachycardia during hypoglycemia in diabetics
3. Use cautiously in peripheral arterial disease (though less vasoconstrictive than other beta-blockers)
4. Monitor heart rate and blood pressure regularly during titration

Drug Interactions:

1. Verapamil, diltiazem, digoxin: ↑ Risk of bradycardia or AV block
2. Amiodarone: Additive heart rate reduction
3. Insulin/oral hypoglycemics: May obscure hypoglycemia symptoms
4. NSAIDs (e.g., ibuprofen): May reduce antihypertensive efficacy
5. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.