Product Information:

MOXIGET IV 400mg/250mL Injection is a ready-to-use intravenous infusion solution containing Moxifloxacin 400mg in 250mL of isotonic vehicle (typically 0.8% saline or 5% dextrose). Moxifloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes for DNA replication, transcription, and repair—resulting in rapid bactericidal activity.

This formulation provides convenient, premixed administration for moderate to severe community-acquired infections in hospitalized or outpatient settings.

⚠️ Important Safety Note: Fluoroquinolones like moxifloxacin carry Black Box Warnings (FDA/DRAP) for:

1. Tendonitis and tendon rupture (especially in elderly or corticosteroid users)
2. Irreversible peripheral neuropathy
3. Exacerbation of myasthenia gravis
4. CNS effects (anxiety, insomnia, seizures)
5. Reserve for infections with no safer alternatives.

Uses of (MOXIGET IV 400MG / 250ML INJ):

1. Community-acquired pneumonia (including multidrug-resistant S. pneumoniae)
2. Acute bacterial sinusitis (when oral therapy not feasible)
3. Complicated skin and skin structure infections
4. Intra-abdominal infections (in combination with metronidazole)
5. Empirical therapy in febrile neutropenia (in select protocols)

Key Benefits of (MOXIGET IV 400MG / 250ML INJ):

1. Once-daily dosing improves adherence and nursing convenience
2. Premixed, ready-to-infuse—no reconstitution or dilution needed
3. Excellent tissue penetration (lungs, sinuses, skin, intra-abdominal organs)
4. Activity against Gram-positive, Gram-negative, and atypical pathogens (Legionella, Mycoplasma, Chlamydia)

How To Use (MOXIGET IV 400MG / 250ML INJ):

1. Administered by intravenous infusion over 60 minutes.
2. Do not give as IV bolus or IM injection.
3. Standard adult dose: One 250mL bag (400mg) once daily
4. Duration: Typically 7–14 days, depending on infection severity
5. Hydrate adequately during therapy

When Not to Use (MOXIGET IV 400MG / 250ML INJ):

Do not use if you have:

1. Hypersensitivity to moxifloxacin or other fluoroquinolones
2. History of fluoroquinolone-associated tendon disorders
3. Myasthenia gravis
4. Pregnancy, breastfeeding, or pediatric patients (<18 years—risk of cartilage damage)
5. Known QT prolongation or concurrent use of QT-prolonging drugs (e.g., amiodarone, erythromycin)

Side Effects of (MOXIGET IV 400MG / 250ML INJ):

Common: Nausea, diarrhea, headache, dizziness, infusion site reaction.

Serious (require immediate discontinuation):

1. Tendon pain/swelling (stop at first sign—Achilles most common)
2. Numbness, tingling, burning pain (peripheral neuropathy—may be permanent)
3. Muscle weakness or breathing difficulty (myasthenia gravis exacerbation)
4. Severe diarrhea (Clostridioides difficile-associated colitis)
5. QT prolongation, hepatotoxicity, photosensitivity
6. Seek emergency care for tendon rupture, seizures, or anaphylaxis.

Dosage: (MOXIGET IV 400MG / 250ML INJ):

1. Adults: 400mg IV once daily
2. Renal or hepatic impairment: No dose adjustment needed (mild-moderate); avoid in severe liver disease
3. Elderly: Use with caution—higher risk of tendon and CNS effects

Who It’s For (MOXIGET IV 400MG / 250ML INJ):

Hospitalized or ambulatory adults with moderate to severe bacterial infections requiring IV therapy, especially when oral fluoroquinolones are not suitable.

Warnings & Precautions:

1. Avoid sun exposure—use sunscreen (phototoxicity risk)
2. Discontinue at first sign of tendon pain or neuropathy
3. Monitor for CNS effects (anxiety, confusion, hallucinations)
4. Do not combine with NSAIDs (↑ seizure risk) or QT-prolonging drugs
5. Use extreme caution in elderly and corticosteroid users

Drug Interactions:

1. Antacids, sucralfate, iron, zinc: ↓ Absorption (less relevant for IV, but caution if switching to oral)
2. Warfarin: ↑ INR—monitor closely
3. NSAIDs: ↑ Risk of CNS stimulation and seizures
4. QT-prolonging drugs: ↑ Risk of torsades de pointes
5. Always inform your doctor about all medications.

Additional Information:

Store below 25°C. Protect from light. Do not freeze. Discard if discolored or contains particles. Keep out of reach of children. For hospital or clinical use only. Available by prescription in Pakistan.