Product Information:

MOXIGET 400mg Tablets contain Moxifloxacin 400mg, a broad-spectrum fluoroquinolone antibiotic. Moxifloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV—enzymes essential for DNA replication, transcription, and repair—leading to rapid bacterial cell death.

This oral formulation is used for moderate to severe community-acquired infections where outpatient therapy is appropriate.

⚠️ Important Safety Note: Fluoroquinolones like moxifloxacin carry Black Box Warnings (FDA/DRAP) for:

1. Tendonitis and tendon rupture (especially in elderly or corticosteroid users)
2. Irreversible peripheral neuropathy
3. Exacerbation of myasthenia gravis
4. CNS effects (anxiety, insomnia, seizures)
5. Use only when no safer alternatives exist.

Uses of (MOXIGET 400MG TABLETS):

1. Community-acquired pneumonia
2. Acute bacterial sinusitis (when other options are unsuitable)
3. Acute exacerbations of chronic bronchitis
4. Complicated skin and skin structure infections
5. Intra-abdominal infections (in combination with metronidazole)

Key Benefits of (MOXIGET 400MG TABLETS):

1. Once-daily dosing improves adherence
2. Excellent penetration into lungs, sinuses, skin, and intra-abdominal tissues
3. Activity against Gram-positive, Gram-negative, and atypical pathogens (Legionella, Mycoplasma, Chlamydia)
4. Short-course therapy possible (e.g., 7 days for pneumonia)

How To Use (MOXIGET 400MG TABLETS):

1. Take one tablet once daily with or without food.
2. Swallow whole with water—do not crush or chew.
3. Complete the full prescribed course—even if symptoms improve early.
4. Stay well-hydrated to prevent crystalluria.

When Not to Use (MOXIGET 400MG TABLETS):

Do not use if you have:

1. Hypersensitivity to moxifloxacin or other fluoroquinolones
2. History of fluoroquinolone-associated tendon disorders
3. Myasthenia gravis
4. Pregnancy, breastfeeding, or children/adolescents (<18 years—risk of cartilage damage)
5. Known QT prolongation or concurrent use of QT-prolonging drugs (e.g., amiodarone, erythromycin)

Side Effects of (MOXIGET 400MG TABLETS):

Common: Nausea, diarrhea, headache, dizziness, insomnia.

Serious (discontinue immediately and seek medical help):

1. Tendon pain, swelling, or rupture (Achilles tendon most common)—stop at first sign
2. Numbness, tingling, or burning pain (peripheral neuropathy—may be permanent)
3. Worsening muscle weakness or breathing difficulty (myasthenia gravis exacerbation)
4. Severe watery or bloody diarrhea (Clostridioides difficile-associated colitis)
5. Photosensitivity, hepatotoxicity, QT prolongation, seizures
6. Seek emergency care for signs of anaphylaxis or tendon rupture.

Dosage: (MOXIGET 400MG TABLETS):

1. Community-acquired pneumonia: 400mg once daily for 7–14 days
2. Acute bacterial sinusitis: 400mg once daily for 10 days
3. Chronic bronchitis exacerbation: 400mg once daily for 5–10 days
4. Skin infections: 400mg once daily for 7–21 days
5. Intra-abdominal infections: 400mg once daily for 5–14 days (with metronidazole)
6. Renal/hepatic impairment: No dose adjustment needed in mild-moderate cases

Who It’s For (MOXIGET 400MG TABLETS):

Adults with moderate to severe bacterial infections where oral fluoroquinolone therapy is clinically justified. Not for viral infections, mild sinusitis, or first-line uncomplicated UTIs.

Warnings & Precautions:

1. Avoid direct sunlight—use sunscreen and protective clothing (phototoxicity risk)
2. Discontinue immediately at first sign of tendon pain or neurological symptoms
3. Use extreme caution in elderly patients and those on corticosteroids
4. Do not combine with NSAIDs (↑ risk of seizures) or QT-prolonging medications
5. Monitor for mood changes, sleep disturbances, or new-onset joint pain

Drug Interactions:

1. Antacids, iron, zinc, calcium, sucralfate: ↓ Absorption—administer ≥4 hours apart
2. Warfarin: May increase INR—monitor closely
3. NSAIDs (e.g., ibuprofen, diclofenac): ↑ Risk of CNS stimulation and seizures
4. QT-prolonging drugs: ↑ Risk of torsades de pointes
5. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date on the blister pack. Available by prescription only in Pakistan.