Product Information:

MIURA D Cholecalciferol 5mg/mL 5S is a high-potency vitamin D3 (cholecalciferol) oral solution, supplied in a pack of 5 single-use vials or ampoules, each containing 1 mL of solution. With a concentration of 5 mg/mL, this equals 200,000 IU of vitamin D3 per mL (since 1 mg cholecalciferol = 40,000 IU).

This formulation is designed for supervised, short-course therapy to rapidly correct severe vitamin D deficiency in adults and adolescents. The “5S” indicates 5 single-dose units, promoting hygiene, accurate dosing, and reduced risk of contamination or overdose.

⚠️ Critical Safety Note:

1. Extremely high potency: 1 mL = 200,000 IU
2. Not for daily or self-administered use
3. Use only under physician supervision with confirmed deficiency

Uses of (MIURA D CHOLECALCIFEROL 5MG/ML 5S):

1. Rapid repletion of vitamin D stores in severe deficiency (serum 25(OH)D <10–12 ng/mL)
2. Treatment of osteomalacia or nutritional rickets
3. Preoperative optimization in deficient patients
4. Therapy in malabsorption syndromes (e.g., celiac disease, post-bariatric surgery)
5. Short-course loading regimen in high-risk individuals (e.g., elderly with fractures)

Key Benefits of (MIURA D CHOLECALCIFEROL 5MG/ML 5S):

1. Single-use vials ensure sterility and precise dosing
2. Enables rapid correction with fewer clinic visits
3. Avoids pill burden in high-dose protocols
4. Ideal for patients who cannot swallow tablets

How To Use (MIURA D CHOLECALCIFEROL 5MG/ML 5S):

1. Use only as prescribed by a doctor.
2. Administer with a meal containing fat to enhance absorption.
3. Each vial contains 1 mL = 200,000 IU—do not use the entire vial unless directed.
4. Typical regimens (examples only):
5. Option 1: 0.5 mL (100,000 IU) once weekly for 2 weeks (total 2 vials used)
6. Option 2: 1 mL (200,000 IU) as a single dose, repeated after 4–8 weeks if needed
7. Discard unused portion of opened vial—do not store or reuse

When Not to Use (MIURA D CHOLECALCIFEROL 5MG/ML 5S):

Do not use if you have:

1. Hypercalcemia or hypercalciuria
2. Sarcoidosis, tuberculosis, or other granulomatous diseases
3. Primary hyperparathyroidism
4. Hypersensitivity to cholecalciferol
5. Known vitamin D toxicity

Side Effects of (MIURA D CHOLECALCIFEROL 5MG/ML 5S):

Safe when used correctly. Overdose or misuse may cause:

1. Nausea, vomiting, constipation
2. Excessive thirst, frequent urination
3. Weakness, confusion, kidney stones
4. Life-threatening hypercalcemia
5. Seek emergency care if these occur.

Dosage Guidance:

1. Total strength per vial: 200,000 IU (1 mL)
2. Common adult regimens:
3. 100,000–200,000 IU once weekly for 2–6 weeks
4. Total cumulative dose: 300,000–600,000 IU over several weeks
5. Pediatric use: Only with extreme caution and weight-based calculation
6. Never self-adjust dose

Who It’s For (MIURA D CHOLECALCIFEROL 5MG/ML 5S):

1. Adults with severe, lab-confirmed vitamin D deficiency
2. Patients requiring rapid repletion before surgery or during pregnancy
3. Individuals under endocrinology or internal medicine care

Warnings & Precautions:

1. Confirm deficiency with blood test before use
2. Monitor serum calcium, phosphate, and 25(OH)D levels after treatment
3. Avoid concurrent high-dose calcium supplements
4. Keep out of reach of children—accidental ingestion of one vial can be fatal

Drug Interactions:

1. Thiazide diuretics: ↑ Risk of hypercalcemia
2. Digoxin: Hypercalcemia increases arrhythmia risk
3. Corticosteroids: May reduce vitamin D response
4. Always inform your doctor about all medications.

Additional Information:

Store below 25°C, protected from light. Use immediately after opening. Each box contains 5 single-use 1mL vials. Available by prescription only in Pakistan.