Product Information:

LUMATEP 42mg Capsules contain Lumefantrine 42mg, always used in fixed-dose combination with Artemether (typically 20mg) as part of Artemether-Lumefantrine (AL) therapy. Lumefantrine is a benzylquinoline antimalarial that disrupts the parasite’s ability to detoxify heme, leading to accumulation of toxic heme and parasite death.

⚠️ Important Note:

LUMATEP 42mg is NOT used alone. It is part of a combination regimen—each dose consists of one Artemether 20mg + Lumefantrine 120mg capsule. The "42mg" labeling may refer to lumefantrine content per unit in some regional formulations, but standard WHO-recommended AL contains 120mg lumefantrine per capsule/tablet.

If your product is labeled “LUMATEP 42mg” as a single-entity capsule, it is not standard and may indicate:

1. A labeling discrepancy (e.g., pack size or local naming variation),
2. A non-WHO-compliant product, or
3. A misinterpretation (e.g., 42mg is not a recognized monotherapy dose).

Always confirm the full composition on the package.

If LUMATEP Contains Artemether + Lumefantrine (Standard Combination):

Uses:

1. First-line treatment of uncomplicated Plasmodium falciparum malaria, including chloroquine-resistant strains
2. Recommended by WHO for adults and children ≥5 kg

Dosage Regimen (Standard AL):

1. Total course: 6 doses over 3 days
2. Dosing schedule:
3. Dose 1: At diagnosis
4. Dose 2: 8 hours after first dose
5. Doses 3–6: Every 12 hours (i.e., morning and evening) for the next 2 days
6. Per dose:
7. Adults (>35 kg): 4 tablets/capsules (each = 20mg artemether + 120mg lumefantrine)
8. Children: Weight-based dosing

Key Benefits:

1. Rapid parasite clearance (artemether) + long half-life prevention of recrudescence (lumefantrine)
2. WHO-prequalified and widely used globally
3. Oral formulation suitable for outpatient use

How to Use:

1. Take with food or milk (fat increases lumefantrine absorption by 2–3x)
2. Complete all 6 doses—even if symptoms improve early
3. Do not skip doses

Side Effects:

Common: Headache, dizziness, nausea, vomiting, loss of appetite.

Rare: Palpitations, sleep disturbances, mild bradycardia.

Serious (rare): QT prolongation (avoid with other QT-prolonging drugs)

When Not to Use:

1. First trimester of pregnancy (unless benefit outweighs risk)
2. Known hypersensitivity to artemisinin derivatives or lumefantrine
3. Severe malaria (requires IV artesunate)

Critical Safety Advice:

✅ Only use LUMATEP if it is confirmed to be part of an Artemether-Lumefantrine combination.

❌ Do not use lumefantrine alone—it is ineffective as monotherapy and promotes resistance.

🔍 Check packaging: Look for “Artemether 20mg + Lumefantrine 120mg” per capsule/tablet.

💊 In Pakistan, common brand names include Coartem®, Lumartem, or Artecom—verify authenticity.

If Truly Labeled as "Lumefantrine 42mg" Alone:

This is not a standard or approved antimalarial regimen. Do not use without confirmation from a physician or pharmacist. Malaria treatment requires combination therapy to prevent drug resistance and ensure efficacy.

Additional Information:

Store below 30°C in a dry place. Keep out of reach of children. Available by prescription in Pakistan. Always complete the full course to prevent treatment failure.