Product Information:

LIPIGET EZ 40mg + 10mg Tablets is a fixed-dose combination of:

1. Atorvastatin 40mg – a potent statin that inhibits HMG-CoA reductase in the liver, significantly reducing endogenous cholesterol synthesis
2. Ezetimibe 10mg – a cholesterol absorption inhibitor that blocks the NPC1L1 transporter in the small intestine, decreasing dietary and biliary cholesterol uptake

This high-efficacy dual therapy provides complementary mechanisms for intensive LDL-cholesterol lowering, often used in patients at very high cardiovascular risk or with familial hypercholesterolemia.

Uses of (LIPIGET EZ 40MG + 10MG TABLETS):

1. Primary hyperlipidemia (heterozygous familial and non-familial)
2. Mixed dyslipidemia (Fredrickson Types IIa and IIb)
3. Homozygous familial hypercholesterolemia (as adjunctive therapy)
4. Patients not achieving LDL goals on high-intensity statin monotherapy
5. Secondary prevention in very high-risk patients (e.g., recent ACS, diabetes with target organ damage, established CVD)

Key Benefits of (LIPIGET EZ 40MG + 10MG TABLETS):

1. Reduces LDL cholesterol by up to 60–65%—greater than either agent alone
2. Also lowers total cholesterol, triglycerides, and apolipoprotein B
3. Modestly increases HDL ("good") cholesterol
4. Once-daily dosing improves long-term adherence
5. May reduce statin dose in some cases while maintaining efficacy

How To Use (LIPIGET EZ 40MG + 10MG TABLETS):

1. Take one tablet once daily, with or without food (preferably in the evening, though atorvastatin is effective at any time).
2. Swallow whole with water—do not crush or chew.
3. Continue heart-healthy diet, exercise, and weight management.
4. Monitor lipid profile, liver enzymes, and muscle symptoms regularly.

When Not to Use (LIPIGET EZ 40MG + 10MG TABLETS):

Do not use if you have:

1. Active liver disease or unexplained persistent elevations in liver transaminases
2. Hypersensitivity to atorvastatin, ezetimibe, or any excipients
3. Pregnancy or breastfeeding (risk of fetal harm)
4. Concomitant use of strong CYP3A4 inhibitors (e.g., itraconazole, clarithromycin, HIV protease inhibitors)—contraindicated with atorvastatin 40mg+

Side Effects of (LIPIGET EZ 40MG + 10MG TABLETS):

Common: Headache, diarrhea, abdominal pain, muscle aches, fatigue, nausea.

Rare: Elevated liver enzymes, joint pain, insomnia.

Serious (require immediate attention):

1. Myopathy/rhabdomyolysis (unexplained muscle pain, tenderness, weakness, dark urine)
2. Hepatotoxicity (jaundice, dark urine, right upper quadrant pain)
3. Discontinue and seek medical help if these occur.

Dosage: (LIPIGET EZ 40MG + 10MG TABLETS):

1. Adults: One tablet (atorvastatin 40mg + ezetimibe 10mg) once daily
2. Maximum recommended atorvastatin dose with ezetimibe: 80mg/10mg (only if benefit outweighs risk)
3. Not for children <10 years

Who It’s For (LIPIGET EZ 40MG + 10MG TABLETS):

Adults at very high cardiovascular risk or with severe hypercholesterolemia who require intensive lipid-lowering beyond standard statin therapy, including those with clinical ASCVD or familial hypercholesterolemia.

Warnings & Precautions:

1. Baseline and periodic liver function tests are recommended
2. Advise patients to report any unexplained muscle symptoms immediately
3. Avoid grapefruit juice (≥1.2L/day may increase atorvastatin levels)
4. Use caution in elderly, hypothyroid, or renal-impaired patients
5. Temporarily discontinue before major elective surgery

Drug Interactions:

1. Cyclosporine: ↑ Ezetimibe exposure—use with caution
2. Fibrates (e.g., gemfibrozil): ↑ Risk of myopathy—avoid combination if possible
3. Warfarin: Monitor INR (atorvastatin may enhance effect)
4. Strong CYP3A4 inhibitors: Contraindicated with atorvastatin ≥40mg due to ↑ myopathy risk
5. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date on the blister pack. Available by prescription only in Pakistan.