Product Information:

LIPIGET EZ 10/20mg Tablets is a fixed-dose combination of:

1. Ezetimibe 10mg – a cholesterol absorption inhibitor that blocks the NPC1L1 transporter in the small intestine, reducing dietary and biliary cholesterol uptake
2. Atorvastatin 20mg – a statin that inhibits HMG-CoA reductase in the liver, decreasing endogenous cholesterol synthesis

This dual-mechanism therapy provides additive LDL-cholesterol reduction, making it suitable for patients who require more intensive lipid-lowering than monotherapy can achieve.

Uses of (LIPIGET EZ 10/20MG TABLETS):

1. Primary hyperlipidemia (heterozygous familial and non-familial)
2. Mixed dyslipidemia (Fredrickson Types IIa and IIb)
3. Homozygous familial hypercholesterolemia (as adjunctive therapy)
4. Patients not at LDL goal on atorvastatin 20mg or ezetimibe alone
5. Secondary prevention in high-risk cardiovascular patients (e.g., with diabetes, prior MI, or stroke)

Key Benefits of (LIPIGET EZ 10/20MG TABLETS):

1. Reduces LDL cholesterol by up to 50–55% (vs. ~40% with atorvastatin 20mg alone)
2. Also lowers total cholesterol, triglycerides, and apolipoprotein B
3. Modestly increases HDL ("good") cholesterol
4. Once-daily dosing improves adherence
5. May allow lower statin doses in some patients, reducing side effect risk

How To Use (LIPIGET EZ 10/20MG TABLETS):

1. Take one tablet once daily, with or without food, preferably in the evening (though atorvastatin can be taken any time).
2. Swallow whole with water—do not crush or chew.
3. Continue a heart-healthy diet and regular exercise.
4. Monitor lipid profile and liver enzymes as advised by your physician.

When Not to Use (LIPIGET EZ 10/20MG TABLETS):

Do not use if you have:

1. Active liver disease or unexplained persistent elevations in liver transaminases
2. Hypersensitivity to atorvastatin, ezetimibe, or any excipients
3. Pregnancy or breastfeeding (risk of fetal harm)
4. Concomitant use of strong CYP3A4 inhibitors (e.g., itraconazole, clarithromycin, HIV protease inhibitors)—use with caution even at this dose

Side Effects of (LIPIGET EZ 1 0/20MG TABLETS):

Common: Headache, diarrhea, abdominal pain, muscle aches, fatigue, nausea.

Rare: Elevated liver enzymes, joint pain, dizziness.

Serious (rare but require monitoring):

1. Myopathy/rhabdomyolysis (unexplained muscle pain, tenderness, weakness, dark urine)
2. Hepatotoxicity (jaundice, dark urine, right upper quadrant pain)
3. Discontinue and seek immediate medical attention if these occur.

Dosage: (LIPIGET EZ 10/20MG TABLETS):

1. Adults: One tablet (ezetimibe 10mg + atorvastatin 20mg) once daily
2. May be adjusted based on lipid response and tolerability (higher strengths available: e.g., 10/40mg, 10/80mg)
3. Not recommended for children <10 years

Who It’s For (LIPIGET EZ 10/20MG TABLETS):

Adults with moderate to high cardiovascular risk who require intensified LDL-lowering beyond statin monotherapy, including those with familial hypercholesterolemia or statin intolerance at higher doses.

Warnings & Precautions:

1. Check liver function tests before starting and as clinically indicated
2. Advise patients to report muscle symptoms immediately
3. Avoid grapefruit juice (may increase atorvastatin levels)
4. Use caution in elderly, hypothyroid, or renal-impaired patients
5. Temporarily discontinue before major elective surgery

Drug Interactions:

1. Cyclosporine: Significantly ↑ ezetimibe exposure
2. Fibrates (e.g., gemfibrozil): ↑ Risk of myopathy
3. Warfarin: Monitor INR (atorvastatin may enhance anticoagulant effect)
4. Strong CYP3A4 inhibitors: May ↑ atorvastatin plasma levels → ↑ myopathy risk
5. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date on the blister pack. Available by prescription in Pakistan.