Product Information:

LIPIGET EZ 10 Plus 10mg Tablets is a fixed-dose combination of:

1. Atorvastatin 10mg – a statin that inhibits HMG-CoA reductase, reducing cholesterol synthesis in the liver
2. Ezetimibe 10mg – a cholesterol absorption inhibitor that blocks NPC1L1 transporter in the small intestine

This dual-action therapy provides complementary mechanisms to lower LDL ("bad") cholesterol more effectively than either agent alone, and is used for patients who require additional lipid-lowering beyond statin monotherapy.

Uses of (LIPIGET EZ 10 PLUS 1 0MG TABLETS):

1. Primary hyperlipidemia (heterozygous familial and non-familial)
2. Mixed dyslipidemia (Fredrickson Types IIa and IIb)
3. Homozygous familial hypercholesterolemia (as adjunctive therapy)
4. Patients not at LDL goal on atorvastatin or ezetimibe alone
5. Cardiovascular risk reduction in high-risk patients (e.g., diabetes, established CVD)

Key Benefits of (LIPIGET EZ 10 PLUS 10MG TABLETS):

1. Reduces LDL cholesterol by 15–20% more than atorvastatin alone
2. Also lowers total cholesterol, triglycerides, and apolipoprotein B
3. Increases HDL ("good") cholesterol modestly
4. Once-daily dosing improves adherence
5. Lower statin dose may reduce muscle-related side effects

How To Use (LIPIGET EZ 10 PLUS 10MG TABLETS):

1. Take one tablet once daily, with or without food, at the same time each day.
2. Swallow whole with water—do not crush or chew.
3. Continue heart-healthy diet and exercise.
4. Monitor lipid profile and liver enzymes as directed by your doctor.

When Not to Use (LIPIGET EZ 10 PLUS 10MG TABLETS):

Do not use if you have:

1. Active liver disease or unexplained persistent elevations in liver enzymes
2. Hypersensitivity to atorvastatin, ezetimibe, or any excipients
3. Pregnancy or breastfeeding (may harm the fetus or infant)
4. Concomitant use of strong CYP3A4 inhibitors (e.g., itraconazole, clarithromycin, HIV protease inhibitors) with higher atorvastatin doses (less relevant at 10mg but caution still advised)

Side Effects of (LIPIGET EZ 10 PLUS 10MG TABLETS):

Common: Headache, diarrhea, abdominal pain, muscle aches, fatigue.

Rare: Elevated liver enzymes, nausea, joint pain.

Serious (rare):

1. Myopathy/rhabdomyolysis (muscle pain, weakness, dark urine)—risk increases with age, renal impairment, or interacting drugs
2. Hepatotoxicity (jaundice, dark urine, right upper quadrant pain)
3. Discontinue and seek medical help if severe muscle pain or signs of liver injury occur.

Dosage: (LIPIGET EZ 10 PLUS 10MG TABLETS):

1. Adults: One tablet (atorvastatin 10mg + ezetimibe 10mg) once daily
2. May be titrated to higher atorvastatin strengths (e.g., 20/10mg, 40/10mg) based on response and tolerance
3. Not for children <10 years (safety not established)

Who It’s For (LIPIGET EZ 10 PLUS 10MG TABLETS):

Adults with elevated LDL cholesterol who need combination therapy to reach target levels, especially those intolerant to higher statin doses or with familial hypercholesterolemia.

Warnings & Precautions:

1. Monitor liver function tests before and during treatment
2. Report unexplained muscle pain, tenderness, or weakness immediately
3. Avoid grapefruit juice (may increase atorvastatin levels)
4. Use caution in elderly, hypothyroid, or renal-impaired patients
5. Discontinue temporarily before elective major surgery

Drug Interactions:

1. Cyclosporine: ↑ Ezetimibe levels
2. Fibrates (e.g., gemfibrozil): ↑ Risk of myopathy
3. Warfarin: Monitor INR (atorvastatin may enhance effect)
4. Strong CYP3A4 inhibitors: May increase atorvastatin exposure
5. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date on the blister pack. Available by prescription in Pakistan.