Product Information:

LIPIGET 20mg Tablets contain Atorvastatin 20mg, a statin-class lipid-lowering agent. Atorvastatin inhibits HMG-CoA reductase, the key enzyme in cholesterol synthesis in the liver. This results in significant reductions in LDL ("bad") cholesterol and triglycerides, along with a modest increase in HDL ("good") cholesterol.

This moderate-strength formulation is widely used for secondary prevention of cardiovascular disease and in patients requiring more intensive lipid control than lower doses provide.

Uses of (LIPIGET 20MG TABLETS):

1. Primary hyperlipidemia (elevated LDL cholesterol)
2. Mixed dyslipidemia (Fredrickson Types IIa and IIb)
3. Prevention of cardiovascular events (heart attack, stroke) in high-risk patients (e.g., diabetes, hypertension, existing CVD)
4. Adjunct to diet and lifestyle changes in adults and children ≥10 years

Key Benefits of (LIPIGET 20MG TABLETS):

1. Reduces LDL cholesterol by approximately 40–50%
2. Lowers risk of major cardiovascular events and revascularization procedures
3. Once-daily dosing for improved long-term adherence
4. Proven mortality benefit in high-risk populations

How To Use (LIPIGET 20MG TABLETS):

1. Take one tablet once daily, with or without food, at the same time each day.
2. Swallow whole with water—do not crush or chew.
3. Continue heart-healthy diet, regular exercise, and weight management.
4. Monitor lipid profile and liver enzymes as advised by your physician.

When Not to Use (LIPIGET 20MG TABLETS):

Do not use if you have:

1. Active liver disease or unexplained persistent elevations in liver transaminases
2. Hypersensitivity to atorvastatin or any excipients
3. Pregnancy or breastfeeding (risk of fetal harm)

Side Effects of (LIPIGET 20MG TABLETS):

Common: Headache, diarrhea, abdominal pain, muscle aches, fatigue, nausea.

Rare: Elevated liver enzymes, joint pain, insomnia.

Serious (rare but require monitoring):

1. Myopathy/rhabdomyolysis (unexplained muscle pain, tenderness, weakness, dark urine)
2. Hepatotoxicity (jaundice, dark urine, right upper quadrant pain)
3. Discontinue and seek immediate medical attention if these occur.

Dosage: (LIPIGET 20MG TABLETS):

1. Adults: 20mg once daily (common maintenance dose); may be adjusted to 10–80mg based on response
2. Children (10–17 years): 10–20mg once daily (max 20mg/day)
3. Elderly or renal impairment: No routine dose adjustment, but monitor closely

Who It’s For (LIPIGET 20MG TABLETS):

Adults with moderate to high cardiovascular risk, established atherosclerotic disease, or those who did not achieve LDL goals on 10mg. Also suitable for adolescents with familial hypercholesterolemia.

Warnings & Precautions:

1. Perform baseline and periodic liver function tests
2. Advise patients to report any unexplained muscle symptoms immediately
3. Avoid excessive grapefruit juice (>1.2 L/day)—may increase atorvastatin levels
4. Use caution in patients with hypothyroidism, renal impairment, or history of muscle disorders

Drug Interactions:

1. Strong CYP3A4 inhibitors (e.g., clarithromycin, itraconazole, HIV protease inhibitors): ↑ Risk of myopathy
2. Cyclosporine, fibrates (e.g., gemfibrozil): ↑ Risk of muscle toxicity
3. Warfarin: May enhance anticoagulant effect—monitor INR
4. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date on the blister pack. Available by prescription in Pakistan.