Product Information:

LEFLOX 750mg Tablets contain Levofloxacin 750mg, a broad-spectrum fluoroquinolone antibiotic. Levofloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair—leading to bacterial cell death.

This high-strength formulation is reserved for severe or resistant infections requiring once-daily dosing with enhanced tissue penetration.

⚠️ Important Safety Note: Fluoroquinolones like levofloxacin carry FDA/DRAP Black Box Warnings for:

1. Tendonitis and tendon rupture (especially in elderly or on corticosteroids)
2. Peripheral neuropathy (may be irreversible)
3. Exacerbation of myasthenia gravis
4. CNS effects (seizures, anxiety, insomnia)
5. Use only when no safer alternatives exist.

Uses of (LEFLOX 750MG TABLETS):

1. Community-acquired pneumonia (including multidrug-resistant S. pneumoniae)
2. Acute bacterial sinusitis (when other options are unsuitable)
3. Complicated skin and skin structure infections
4. Chronic bacterial prostatitis
5. Urinary tract infections (acute pyelonephritis or complicated UTIs)
6. Inhalational anthrax (post-exposure)

Key Benefits of (LEFLOX 750MG TABLETS):

1. Once-daily dosing improves adherence
2. Excellent lung, prostate, and urinary tract penetration
3. Activity against atypical pathogens (Legionella, Mycoplasma, Chlamydia)
4. Short-course therapy possible (e.g., 5 days for pneumonia)

How To Use (LEFLOX 750MG TABLETS):

1. Take once daily with or without food, but avoid dairy products, antacids, or iron/zinc supplements within 2 hours (they reduce absorption).
2. Swallow whole with water—do not crush or chew.
3. Complete the full course even if symptoms improve.
4. Hydrate well to prevent crystalluria.

When Not to Use (LEFLOX 750MG TABLETS):

Do not use if you have:

1. Hypersensitivity to levofloxacin or other fluoroquinolones
2. History of tendon disorders related to fluoroquinolones
3. Myasthenia gravis
4. Pregnancy, breastfeeding, or children/adolescents (risk of cartilage damage)
5. Prolonged QT interval or concurrent use of QT-prolonging drugs

Side Effects of (LEFLOX 750MG TABLETS):

Common: Nausea, headache, diarrhea, insomnia, dizziness.

Serious (require immediate discontinuation):

1. Tendon pain/swelling (Achilles tendon most common)—stop at first sign
2. Numbness, tingling, or burning pain (peripheral neuropathy)
3. Worsening myasthenia gravis (muscle weakness, breathing difficulty)
4. Severe diarrhea (Clostridioides difficile-associated)
5. QT prolongation, photosensitivity, liver injury
6. Seek emergency care for tendon rupture, seizures, or severe rash.

Dosage: (LEFLOX 750MG TABLETS):

1. Community-acquired pneumonia: 750mg once daily for 5 days
2. Acute bacterial sinusitis: 750mg once daily for 5 days
3. Complicated UTI/pyelonephritis: 750mg once daily for 5–10 days
4. Chronic bacterial prostatitis: 750mg once daily for 28 days
5. Renal impairment (CrCl <50 mL/min): Dose adjustment required

Who It’s For (LEFLOX 750MG TABLETS):

Adults with severe, confirmed bacterial infections where benefits outweigh risks. Not for mild infections, viral illnesses, or first-line UTI/sinusitis treatment.

Warnings & Precautions:

1. Avoid sun exposure—use sunscreen (risk of phototoxicity)
2. Discontinue at first sign of tendon pain or neuropathy
3. Monitor for CNS effects (anxiety, confusion, hallucinations)
4. Do not combine with NSAIDs (↑ seizure risk) or QT-prolonging drugs
5. Use extreme caution in elderly patients and those on corticosteroids

Drug Interactions:

1. Antacids, sucralfate, iron, zinc, didanosine: ↓ Absorption—space doses by 2 hours
2. Warfarin: ↑ INR—monitor closely
3. NSAIDs: ↑ Risk of CNS stimulation and seizures
4. QT-prolonging drugs (e.g., amiodarone, erythromycin): ↑ Risk of arrhythmia
5. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription only in Pakistan.