Product Information:

LEFLOX 250mg Tablets contain Levofloxacin 250mg, a broad-spectrum fluoroquinolone antibiotic. Levofloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV—enzymes essential for DNA replication, transcription, and repair—leading to rapid bacterial cell death.

This lower-strength formulation is typically used for mild to moderate infections or in patients requiring dose adjustment due to renal impairment or tolerability concerns.

⚠️ Important Safety Note: Fluoroquinolones like levofloxacin carry Black Box Warnings (FDA/DRAP) for:

1. Tendonitis and tendon rupture (especially in elderly or corticosteroid users)
2. Irreversible peripheral neuropathy
3. Exacerbation of myasthenia gravis
4. CNS effects (anxiety, insomnia, seizures)
5. Use only when safer alternatives are not appropriate.

Uses of (LEFLOX 250MG TABLETS):

1. Uncomplicated urinary tract infections (acute cystitis)
2. Mild community-acquired pneumonia
3. Acute bacterial sinusitis (when other options are unsuitable)
4. Chronic bacterial prostatitis (as part of longer-course therapy)
5. Step-down oral therapy after IV antibiotics

Key Benefits of (LEFLOX 250MG TABLETS):

1. Once-daily dosing for improved adherence
2. Good tissue penetration (urinary tract, lungs, prostate)
3. Activity against common Gram-negative and atypical pathogens
4. Lower dose may reduce side effect risk in sensitive patients

How To Use (LEFLOX 250MG TABLETS):

1. Take once daily with or without food.
2. Swallow whole with water—do not crush or chew.
3. Avoid taking within 2 hours of dairy products, antacids, iron, or zinc supplements (they reduce absorption).
4. Complete the full prescribed course—even if symptoms improve.
5. Stay well-hydrated to prevent crystalluria.

When Not to Use (LEFLOX 250MG TABLETS):

Do not use if you have:

1. Hypersensitivity to levofloxacin or other fluoroquinolones
2. History of tendon disorders related to fluoroquinolones
3. Myasthenia gravis
4. Pregnancy, breastfeeding, or children/adolescents (risk of cartilage damage)
5. Known QT prolongation or concurrent use of QT-prolonging drugs

Side Effects of (LEFLOX 250MG TABLETS):

Common: Nausea, headache, diarrhea, dizziness, insomnia.

Serious (discontinue immediately if occurs):

1. Tendon pain or swelling (especially Achilles)—stop at first sign
2. Numbness, tingling, or burning sensation (peripheral neuropathy—may be permanent)
3. Muscle weakness or breathing difficulty (myasthenia gravis worsening)
4. Severe diarrhea (Clostridioides difficile-associated)
5. Photosensitivity, liver enzyme elevation, QT prolongation
6. Seek emergency care for signs of tendon rupture, seizures, or anaphylaxis.

Dosage: (LEFLOX 250MG TABLETS):

1. Uncomplicated UTI: 250mg once daily for 3 days
2. Community-acquired pneumonia: 250–500mg once daily for 7–14 days
3. Chronic prostatitis: 250–500mg once daily for 28 days
4. Renal impairment (CrCl <50 mL/min): Dose reduction required

Who It’s For (LEFLOX 250MG TABLETS):

Adults with mild to moderate bacterial infections where fluoroquinolone use is justified. Not for viral infections, simple sinusitis, or first-line uncomplicated UTI treatment in regions with high resistance.

Warnings & Precautions:

1. Avoid sun exposure—use sunscreen and protective clothing (phototoxicity risk)
2. Discontinue at first sign of tendon pain or neurological symptoms
3. Use caution in elderly patients and those on corticosteroids
4. Do not combine with NSAIDs (↑ seizure risk) or QT-prolonging medications

Drug Interactions:

1. Antacids, iron, zinc, sucralfate: ↓ Absorption—administer 2 hours apart
2. Warfarin: May increase INR—monitor closely
3. NSAIDs: ↑ Risk of CNS stimulation and seizures
4. QT-prolonging drugs (e.g., erythromycin, amiodarone): ↑ Risk of arrhythmia
5. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription only in Pakistan.