Product Information:

INSUGET R Vials contain Regular Human Insulin, a short-acting insulin used to control blood glucose levels in patients with diabetes mellitus. It is identical in structure to endogenous human insulin and works by facilitating cellular uptake of glucose, particularly in muscle and fat tissues, while inhibiting hepatic glucose production.

Regular insulin is a clear, colorless solution and is typically used for mealtime coverage or in emergency settings (e.g., diabetic ketoacidosis).

Uses of (INSUGET R VIALS):

1. Management of type 1 and type 2 diabetes mellitus as part of basal-bolus therapy
2. Mealtime (prandial) insulin coverage when used with intermediate- or long-acting insulin
3. Intravenous treatment of diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS)
4. In-hospital glycemic control in critically ill patients

Key Benefits of (INSUGET R VIALS):

1. Rapid onset of action suitable for mealtime glucose control
2. Can be administered subcutaneously or intravenously (unlike analogs)
3. Cost-effective alternative to rapid-acting insulin analogs (e.g., lispro, aspart)
4. Essential for emergency management of acute hyperglycemic crises

How To Use (INSUGET R VIALS):

1. Subcutaneous use: Inject 30 minutes before meals (due to slower onset vs. analogs).
2. Intravenous use: Only in hospital settings under strict monitoring (for DKA/HHS).
3. Administer subcutaneously in the abdomen, thigh, or upper arm.
4. Rotate injection sites to prevent lipodystrophy.
5. Do not shake—solution should remain clear and colorless.
6. Never share vials or syringes.

When Not to Use (INSUGET R VIALS):

Do not use if you have:

1. Hypersensitivity to human insulin or excipients (e.g., zinc, metacresol, glycerol)
2. Episodes of hypoglycemia without awareness
3. During episodes of hypoglycemia

Side Effects of (INSUGET R VIALS):

Common: Hypoglycemia (sweating, tremor, dizziness, hunger, palpitations), injection site reactions (redness, itching).

Rare: Weight gain, peripheral edema, allergic skin reactions.

Serious (rare):

1. Severe hypoglycemia (confusion, seizures, loss of consciousness)
2. Anaphylaxis (angioedema, bronchospasm)
3. Hypokalemia (especially during IV infusion)
4. Seek emergency care for severe hypoglycemia or anaphylaxis.

Dosage: (INSUGET R VIALS):

1. Individualized based on weight, carbohydrate intake, and glycemic targets.
2. Typical mealtime dose: 0.1–0.2 units/kg per meal (adjusted based on pre-meal glucose and carb count).
3. IV infusion (DKA): 0.1 units/kg/hour after initial bolus (under supervision).
4. Onset: 30–60 minutes | Peak: 2–4 hours | Duration: 5–8 hours

Who It’s For (INSUGET R VIALS):

Adults and adolescents with type 1 or type 2 diabetes requiring prandial insulin coverage, especially those using vial-and-syringe delivery or needing IV insulin in acute settings.

Warnings & Precautions:

1. Hypoglycemia risk increases with delayed meals, alcohol, or excessive exercise
2. Monitor blood glucose closely—especially during dose titration
3. Do not use if solution is cloudy, discolored, or contains particles
4. Cold insulin may cause injection pain—allow to reach room temperature before use
5. Inform healthcare team before surgery or illness

Drug Interactions:

1. Beta-blockers: May mask tachycardia—a sign of hypoglycemia
2. Corticosteroids, thiazides, sympathomimetics: May reduce insulin efficacy
3. ACE inhibitors, salicylates, sulfonamides: May enhance hypoglycemic effect
4. Always inform your doctor about all medications.

Additional Information:

Store unopened vials in a refrigerator (2–8°C). Once in use, keep at room temperature (<30°C) for up to 28 days. Protect from light and heat. Do not freeze. Available by prescription in Pakistan.