Product Information:

INSUGET 70/30 Vials contain a premixed suspension of human insulin in the ratio of 70% intermediate-acting insulin (NPH) and 30% short-acting insulin (Regular). This combination provides both basal (background) and prandial (mealtime) glucose control in patients with diabetes mellitus.

It is a biphasic human insulin formulation, appearing as a cloudy white suspension that must be gently resuspended before each use.

Uses of (INSUGET 70/30 VIALS):

1. Management of type 1 and type 2 diabetes mellitus requiring both basal and bolus insulin coverage
2. Patients needing simplified insulin regimens (typically twice-daily dosing)
3. Those unable to use insulin analogs due to cost or availability

Key Benefits of (INSUGET 70/30 VIALS):

1. Dual action: NPH provides background insulin; Regular insulin covers mealtime spikes
2. Cost-effective alternative to insulin analogs
3. Predictable action profile when used consistently
4. Suitable for vial-and-syringe administration

How To Use (INSUGET 70/30 VIALS):

1. Gently roll the vial between palms until uniformly cloudy—do not shake vigorously.
2. Administer subcutaneously (usually abdomen, thigh, or upper arm).
3. Typical regimen: Injected 30 minutes before breakfast and dinner.
4. Rotate injection sites to prevent lipodystrophy.
5. Do not administer intravenously or intramuscularly unless directed in emergency settings.
6. Never share vials or syringes.

When Not to Use (INSUGET 70/30 VIALS):

Do not use if you have:

1. Hypersensitivity to human insulin or any excipients (e.g., zinc, glycerol, metacresol)
2. Episodes of hypoglycemia without awareness
3. During episodes of diabetic ketoacidosis (use short-acting insulin IV instead)

Side Effects of (INSUGET 70/30 VIALS):

Common: Hypoglycemia (sweating, tremor, dizziness, hunger, palpitations), injection site reactions (redness, itching, lipodystrophy).

Rare: Weight gain, peripheral edema, allergic reactions (rash, urticaria).

Serious (rare):

1. Severe hypoglycemia (confusion, seizures, loss of consciousness)
2. Generalized hypersensitivity (anaphylaxis—angioedema, bronchospasm)
3. Hypokalemia (due to insulin’s intracellular potassium shift)
4. Seek emergency care for severe hypoglycemia or anaphylaxis.

Dosage: (INSUGET 70/30 VIALS):

1. Individualized based on weight, diet, activity, and glycemic targets.
2. Typical starting dose: 0.5–1.0 units/kg/day, split two-thirds before breakfast, one-third before dinner.
3. Adjust based on fasting and pre-dinner blood glucose levels.
4. Onset: 30–60 minutes | Peak: 2–12 hours | Duration: Up to 24 hours

Who It’s For (INSUGET 70/30 VIALS):

Adults and adolescents with type 1 or type 2 diabetes who require a simple, fixed-ratio insulin regimen and are able to adhere to consistent meal timing and carbohydrate intake.

Warnings & Precautions:

1. Hypoglycemia risk increases with delayed meals, excessive exercise, or alcohol
2. Monitor blood glucose regularly—especially during dose titration
3. Do not use if vial shows clumping, frosting, or discoloration
4. Cold insulin may cause injection pain—allow to reach room temperature before use
5. Inform healthcare providers before surgery or illness

Drug Interactions:

1. Beta-blockers: May mask tachycardia—a sign of hypoglycemia
2. Corticosteroids, thiazides, sympathomimetics: May reduce insulin efficacy
3. ACE inhibitors, salicylates, sulfonamides: May enhance hypoglycemic effect
4. Always inform your doctor about all medications.

Additional Information:

Store unopened vials in a refrigerator (2–8°C). Once in use, keep at room temperature (<30°C) for up to 28 days. Protect from light and heat. Do not freeze. Available by prescription in Pakistan.