Product Information:

GONADIL-F Capsules contain a combination of human chorionic gonadotropin (hCG) and follicle-stimulating hormone (FSH), typically derived from human menopausal gonadotropins (hMG). These are purified urinary or recombinant gonadotropins used to stimulate ovarian follicular development in women and support spermatogenesis in men with specific hormonal deficiencies.

⚠️ Note: In Pakistan, "GONADIL-F" commonly refers to a formulation containing 75 IU FSH + 75 IU LH (luteinizing hormone) per vial or capsule-equivalent, though exact composition may vary by manufacturer. Despite the name “capsules,” this product is often supplied as a lyophilized powder for injection—not an oral capsule. Verify dosage form on packaging.

Uses of (GONADIL-F CAPSULES):

1. In women:
2. Ovulation induction in anovulatory infertility (e.g., PCOS)
3. Controlled ovarian stimulation (COS) in assisted reproductive technologies (ART), such as IVF
4. In men:
5. Treatment of hypogonadotropic hypogonadism (low FSH/LH) causing infertility
6. Stimulation of spermatogenesis in select cases of male infertility

Key Benefits of (GONADIL-F CAPSULES):

1. Mimics natural pituitary gonadotropins to restore reproductive function
2. Enables ovulation in anovulatory women
3. Supports follicular maturation in IVF protocols
4. Can improve sperm count and quality in hormonally deficient men

How To Use (GONADIL-F CAPSULES):

1. Administered subcutaneously (SC) or intramuscularly (IM) by a healthcare professional or trained patient.
2. Not taken orally—despite “capsules” in the name, it is a reconstituted injectable.
3. Dosing is highly individualized based on:
4. Baseline hormone levels
5. Ovarian response (monitored via ultrasound and estradiol)
6. Treatment protocol (e.g., IVF vs. ovulation induction)
7. Typical starting dose in women: 75–150 IU FSH daily, adjusted based on response.

When Not to Use (GONADIL-F CAPSULES):

Do not use if you have:

1. Primary ovarian failure or premature menopause
2. Uncontrolled thyroid or adrenal dysfunction
3. Pituitary or hypothalamic tumors
4. Known hypersensitivity to gonadotropins or excipients
5. Pregnancy or breastfeeding
6. Ovarian cysts or enlarged ovaries not due to PCOS
7. Undiagnosed gynecological bleeding

Side Effects of (GONADIL-F CAPSULES):

Common: Injection site reactions, headache, abdominal pain, bloating, mood swings.

Serious (require monitoring):

1. Ovarian Hyperstimulation Syndrome (OHSS): Symptoms include severe abdominal pain, nausea, rapid weight gain, shortness of breath
2. Multiple pregnancy (twins, triplets)
3. Ectopic pregnancy
4. Thromboembolic events (rare)
5. Discontinue and seek immediate care if signs of OHSS or severe pelvic pain occur.

Dosage: (GONADIL-F CAPSULES):

1. Women (ovulation induction): 75–150 IU FSH daily for 7–14 days, adjusted by response
2. IVF protocols: Higher doses (150–300 IU/day) under strict supervision
3. Men: 75–150 IU FSH + LH 2–3 times weekly for 3–12 months
4. Duration: Varies by indication; never self-adjust dose

Who It’s For (GONADIL-F CAPSULES):

1. Women with anovulation due to hypothalamic-pituitary dysfunction
2. Couples undergoing fertility treatment (e.g., IUI, IVF)
3. Men with confirmed hypogonadotropic hypogonadism and low sperm count

Warnings & Precautions:

1. Use only under supervision of a fertility specialist
2. Requires regular monitoring (ultrasound, estradiol levels) to prevent OHSS
3. Not effective in primary ovarian insufficiency or tubal factor infertility
4. Risk of multiple gestation—counsel patients before treatment

Drug Interactions:

1. Clomiphene citrate: May be used sequentially but not concurrently without supervision
2. GnRH agonists/antagonists: Often used together in IVF protocols
3. No significant CYP450 interactions (peptide hormones)

Additional Information:

Store lyophilized powder refrigerated (2–8°C). Protect from light. Reconstitute only with provided diluent. Discard unused solution. Keep out of reach of children. Available by prescription only in Pakistan.