Product Information:

GETZID MR 60mg Tablets contain Gliclazide 60mg in a Modified-Release (MR) formulation. Gliclazide is a second-generation sulfonylurea used to manage type 2 diabetes mellitus. It stimulates insulin secretion from pancreatic beta cells and may offer additional vascular protective effects through antioxidant and antiplatelet properties.

The MR formulation provides gradual, sustained release over 24 hours, enabling once-daily dosing, smoother glycemic control, and a reduced risk of hypoglycemia compared to immediate-release versions.

Uses of (GETZID MR 60MG TABLETS):

1. Monotherapy in adults with type 2 diabetes inadequately controlled by diet, exercise, or lower doses of gliclazide
2. Combination therapy with metformin, SGLT2 inhibitors, DPP-4 inhibitors, or basal insulin
3. Patients requiring intensified but simplified once-daily oral therapy

Key Benefits of (GETZID MR 60MG TABLETS):

1. Once-daily dosing improves adherence
2. Modified-release profile minimizes blood glucose fluctuations
3. Lower hypoglycemia risk compared to other sulfonylureas (e.g., glyburide)
4. Potential cardiovascular benefits due to pleiotropic effects
5. Suitable for long-term diabetes management

How To Use (GETZID MR 60MG TABLETS):

1. Take once daily with breakfast (or the first main meal of the day).
2. Swallow whole with water—do not crush, chew, or split (this would disrupt the modified-release mechanism and cause dose dumping).
3. Take at the same time each day.
4. Do not skip meals—this increases the risk of hypoglycemia.

When Not to Use (GETZID MR 60MG TABLETS):

Do not use if you have:

1. Type 1 diabetes or diabetic ketoacidosis
2. Severe renal impairment (eGFR <30 mL/min) or hepatic failure
3. Hypersensitivity to gliclazide or other sulfonylureas
4. Pregnancy or breastfeeding (insulin is preferred)

Side Effects of (GETZID MR 60MG TABLETS):

Common: Hypoglycemia (sweating, tremor, dizziness, hunger), weight gain, headache, nausea.

Rare: Skin rash, gastrointestinal discomfort, elevated liver enzymes.

Serious (rare but more likely at higher doses):

1. Severe hypoglycemia (confusion, seizures, loss of consciousness)
2. Hemolytic anemia (in G6PD-deficient patients)
3. Cholestatic jaundice or hepatitis
4. Discontinue and seek immediate medical help if severe symptoms occur.

Dosage: (GETZID MR 60MG TABLETS):

1. Typical maintenance dose: 60mg once daily
2. May be increased up to 120mg once daily (maximum dose) based on HbA1c response
3. Not recommended as initial therapy—start with 30mg and titrate upward
4. Elderly or renally impaired: Use with caution; avoid high starting doses

Who It’s For (GETZID MR 60MG TABLETS):

Adults with type 2 diabetes who require stronger glycemic control than 30mg provides but still benefit from a once-daily regimen. Ideal for patients stable on lower doses needing intensification without switching drug classes.

Warnings & Precautions:

1. Hypoglycemia risk is higher than with 30mg—ensure consistent carbohydrate intake
2. Avoid alcohol—may cause disulfiram-like reaction (flushing, nausea) and worsen hypoglycemia
3. Monitor kidney and liver function periodically
4. Inform healthcare providers before surgery or contrast imaging

Drug Interactions:

1. Alcohol: ↑ Risk of hypoglycemia and disulfiram-like reaction
2. Beta-blockers: May mask tachycardia—a key sign of hypoglycemia
3. NSAIDs, sulfonamides, warfarin, fluconazole: May potentiate gliclazide → hypoglycemia
4. Rifampicin: May reduce efficacy
5. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date on the blister pack. Available by prescription in Pakistan.