Product Information:

GETZID MR 30mg Tablets contain Gliclazide 30mg in a Modified-Release (MR) formulation. Gliclazide is a second-generation sulfonylurea used to treat type 2 diabetes mellitus. It works by stimulating insulin secretion from pancreatic beta cells and may also exert antioxidant and antiplatelet effects, offering potential vascular protection.

The MR formulation ensures gradual release over 24 hours, allowing for once-daily dosing with smoother blood glucose control and reduced risk of hypoglycemia compared to immediate-release versions.

Uses of (GETZID MR 30MG TABLETS):

1. Monotherapy in adults with type 2 diabetes not controlled by diet and exercise alone
2. Combination therapy with metformin, SGLT2 inhibitors, DPP-4 inhibitors, or insulin
3. Patients requiring once-daily dosing for improved adherence

Key Benefits of (GETZID MR 30MG TABLETS):

1. Once-daily dosing improves compliance
2. Modified-release profile provides steady glucose control with lower hypoglycemia risk
3. Potential cardiovascular benefits due to antiplatelet and antioxidant properties
4. Suitable for long-term glycemic management

How To Use (GETZID MR 30MG TABLETS):

1. Take once daily with breakfast (or the first main meal of the day).
2. Swallow whole with water—do not crush, chew, or split (this would disrupt the modified-release mechanism).
3. Take at the same time each day.
4. Do not skip meals to avoid hypoglycemia.

When Not to Use (GETZID MR 30MG TABLETS):

Do not use if you have:

1. Type 1 diabetes or diabetic ketoacidosis
2. Severe renal impairment (eGFR <30 mL/min) or hepatic failure
3. Hypersensitivity to gliclazide or other sulfonylureas
4. Pregnancy or breastfeeding (insulin is preferred)

Side Effects of (GETZID MR 30MG TABLETS):

Common: Hypoglycemia (sweating, tremor, dizziness, hunger), headache, nausea, weight gain.

Rare: Skin rash, elevated liver enzymes, gastrointestinal discomfort.

Serious (rare):

1. Severe hypoglycemia (confusion, seizures, loss of consciousness)
2. Hemolytic anemia (in G6PD-deficient patients)
3. Cholestatic jaundice
4. Discontinue and seek medical help if severe reactions occur.

Dosage: (GETZID MR 30MG TABLETS):

1. Starting dose: 30mg once daily
2. May be increased gradually up to 120mg once daily (max dose) based on glycemic response
3. Elderly or renally impaired: Start at 30mg; titrate cautiously
4. Monitor HbA1c every 3 months

Who It’s For (GETZID MR 30MG TABLETS):

Adults with type 2 diabetes who benefit from once-daily sulfonylurea therapy, especially those seeking simplified regimens or at lower risk of hypoglycemia compared to other sulfonylureas.

Warnings & Precautions:

1. Risk of hypoglycemia increases with skipped meals, alcohol, or excessive exercise
2. Avoid alcohol—may cause disulfiram-like reaction (flushing, nausea)
3. Monitor kidney and liver function periodically
4. Inform surgeon/dentist before procedures—temporary discontinuation may be needed

Drug Interactions:

1. Alcohol: ↑ Risk of hypoglycemia and disulfiram-like reaction
2. Beta-blockers: May mask tachycardia—a sign of hypoglycemia
3. NSAIDs, sulfonamides, warfarin, fluconazole: May enhance gliclazide effect → hypoglycemia
4. Rifampicin: May reduce efficacy
5. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date on the blister pack. Available by prescription in Pakistan.