Product Information:

GETRYL 1mg Tablets contain Glimepiride 1mg as the active ingredient. Glimepiride is a second-generation sulfonylurea used to treat type 2 diabetes mellitus. It works by stimulating insulin release from pancreatic beta cells and enhancing insulin sensitivity in peripheral tissues, thereby lowering blood glucose levels.

This low-strength formulation is ideal for initial therapy, elderly patients, or those requiring gentle glycemic control with reduced hypoglycemia risk.

Uses of (GETRYL 1MG TABLETS):

1. Monotherapy in adults with type 2 diabetes mellitus not controlled by diet and exercise alone
2. Combination therapy with metformin, SGLT2 inhibitors, or other antidiabetic agents
3. Initial treatment in elderly or frail patients to minimize hypoglycemia risk

Key Benefits of (GETRYL 1MG TABLETS):

1. Once-daily dosing for improved adherence
2. Lower risk of hypoglycemia compared to higher doses or older sulfonylureas (e.g., glibenclamide)
3. Cardiovascular safety profile superior to some older sulfonylureas
4. Cost-effective oral antidiabetic agent

How To Use (GETRYL 1MG TABLETS):

1. Take once daily with breakfast or the first main meal of the day.
2. Swallow whole with water—do not crush or chew.
3. Take consistently at the same time each day.
4. Do not skip meals while on this medication to avoid hypoglycemia.

When Not to Use (GETRYL 1MG TABLETS):

Do not use if you have:

1. Type 1 diabetes or diabetic ketoacidosis
2. Severe renal or hepatic impairment
3. Hypersensitivity to glimepiride or other sulfonylureas
4. Pregnancy or breastfeeding (insulin is preferred)

Side Effects of (GETRYL 1MG TABLETS):

Common: Hypoglycemia (sweating, tremor, dizziness, hunger), headache, nausea.

Rare: Weight gain, elevated liver enzymes, skin rash.

Serious (very rare):

1. Severe hypoglycemia (confusion, seizures, loss of consciousness)
2. Hemolytic anemia (in G6PD deficiency)
3. Cholestatic jaundice
4. Discontinue and seek medical help if severe reactions occur.

Dosage: (GETRYL 1MG TABLETS):

1. Starting dose: 1mg once daily
2. May be increased gradually (e.g., to 2–4mg/day) based on blood glucose response
3. Maximum dose: 6mg once daily
4. Elderly or renally impaired: Start at 1mg; titrate slowly

Who It’s For (GETRYL 1MG TABLETS):

Adults with type 2 diabetes, especially elderly patients, those with mild hyperglycemia, or individuals initiating sulfonylurea therapy.

Warnings & Precautions:

1. Risk of hypoglycemia increases with skipped meals, alcohol, or excessive exercise
2. Avoid alcohol—may cause disulfiram-like reaction (flushing, nausea)
3. Monitor HbA1c every 3 months and kidney/liver function periodically
4. Inform surgeon/dentist before procedures—may need temporary discontinuation

Drug Interactions:

1. Alcohol: ↑ Risk of hypoglycemia and disulfiram-like reaction
2. Beta-blockers: May mask tachycardia—a sign of hypoglycemia
3. NSAIDs, sulfonamides, warfarin: May enhance glimepiride effect → hypoglycemia
4. Rifampicin: May reduce efficacy
5. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date on the blister pack. Available by prescription in Pakistan.