Product Information:

GETOLIX 150mg Tablets contain Pregabalin 150mg, a gamma-aminobutyric acid (GABA) analog used to treat neuropathic pain, epilepsy, and generalized anxiety disorder. Pregabalin works by binding to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of excitatory neurotransmitters such as glutamate, noradrenaline, and substance P.

The 150mg strength is commonly used as a maintenance or intermediate dose for chronic conditions requiring sustained symptom control.

Uses of (GETOLIX 150MG TAB):

1. Neuropathic pain: Diabetic peripheral neuropathy, postherpetic neuralgia
2. Adjunctive therapy in partial-onset seizures (epilepsy)
3. Generalized Anxiety Disorder (GAD) in adults
4. Fibromyalgia (off-label in some regions)

Key Benefits of (GETOLIX 150MG TAB):

1. Rapid onset of action (within days for pain/anxiety)
2. Once- or twice-daily dosing improves adherence
3. Non-addictive (not a controlled substance in Pakistan, but regulated)
4. Effective for both pain and anxiety symptoms

How To Use (GETOLIX 150MG TAB):

1. Take with or without food, at the same time(s) each day.
2. Swallow whole with water—do not crush or chew.
3. Typical adult dosing:
4. Neuropathic pain / GAD: 150mg daily in 2–3 divided doses (e.g., 75mg twice daily or 50mg three times daily); may increase to 300–600mg/day based on response
5. Epilepsy: 150–600mg/day in 2–3 divided doses
6. Do not stop abruptly—taper gradually over ≥1 week to avoid withdrawal (insomnia, headache, nausea, seizures).

When Not to Use (GETOLIX 150MG TAB):

Do not use if you have:

1. Hypersensitivity to pregabalin or any excipients
2. Severe renal impairment (CrCl <15 mL/min)—requires significant dose adjustment
3. History of angioedema with pregabalin

⚠️ Black Box Warning (Global):

Pregabalin may cause suicidal thoughts or behavior. Monitor for worsening depression or unusual changes in mood/behavior.

Side Effects of (GETOLIX 150MG TAB):

Common:

1. Dizziness, drowsiness, fatigue
2. Peripheral edema (swelling in hands/feet)
3. Weight gain, blurred vision
4. Dry mouth, constipation

Less common:

1. Ataxia, tremor
2. Euphoria or confusion
3. Erectile dysfunction

Serious (rare):

1. Angioedema (facial/throat swelling)—discontinue immediately
2. Suicidal ideation or behavior
3. Rhabdomyolysis (muscle pain, dark urine)—very rare
4. Withdrawal symptoms (seizures, insomnia) if stopped abruptly
5. Seek emergency help if breathing difficulty, severe mood changes, or muscle pain occurs.

Dosage Adjustments:

1. Renal impairment:
2. CrCl 30–60 mL/min: Max 300mg/day
3. CrCl 15–30 mL/min: Max 150mg/day
4. CrCl <15 mL/min: Max 75mg/day
5. Elderly: Start low due to reduced renal function
6. Hepatic impairment: No dose adjustment needed

Who It’s For (GETOLIX 150MG TAB):

Adults with neuropathic pain, epilepsy, or generalized anxiety disorder who require effective, non-opioid symptom management under medical supervision.

Warnings & Precautions:

1. Avoid alcohol—increases CNS depression
2. Use caution when driving or operating machinery
3. Monitor weight and edema regularly
4. Screen for depression/suicidal thoughts before and during therapy
5. Taper slowly when discontinuing

Drug Interactions:

1. CNS depressants (opioids, benzodiazepines, alcohol): ↑ Sedation, respiratory depression
2. Thiazolidinediones (e.g., pioglitazone): ↑ Risk of edema and weight gain
3. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.