Product Information:

GETOFIN 500mg IV Injection contains Ceftriaxone 500mg as the active ingredient. Ceftriaxone is a third-generation cephalosporin antibiotic with broad-spectrum activity against Gram-positive and Gram-negative bacteria, including Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Escherichia coli, Klebsiella spp., and Proteus mirabilis. It works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death.

This intermediate-strength intravenous (IV) formulation is commonly used for moderate infections, pediatric patients, or as part of step-down therapy in adults requiring parenteral antibiotic treatment.

⚠️ Note: Despite the brand name "GETOFIN," this product is not related to finasteride or antifungal agents—it is a cephalosporin antibiotic.

Uses of (GETOFIN 500MG IV INJECTION):

1. Moderate community-acquired pneumonia
2. Uncomplicated to moderately complicated urinary tract infections (UTIs)
3. Skin and soft tissue infections
4. Pediatric bacterial infections (dose adjusted by weight)
5. Intra-abdominal infections (in combination with metronidazole)
6. Surgical prophylaxis in moderate-risk procedures
7. Step-down therapy from higher doses in stable patients

Key Benefits of (GETOFIN 500MG IV INJECTION):

1. Broad-spectrum coverage against common pathogens
2. Long half-life (~8 hours) allows once-daily dosing
3. Excellent penetration into lungs, skin, urinary tract, and inflamed tissues
4. Suitable for outpatient parenteral antibiotic therapy (OPAT)
5. Dual excretion (renal and biliary)—safe in mild renal or hepatic impairment

How To Use (GETOFIN 500MG IV INJECTION):

1. Administered intravenously (IV) by a healthcare professional.
2. Reconstitute with sterile water for injection, then dilute in compatible IV fluid (e.g., 0.9% NaCl or 5% dextrose).
3. Infuse over 30 minutes.
4. Standard adult dose: 500mg–2g once daily (depending on infection severity)
5. Pediatric dose: Typically 25–50 mg/kg/day (max 4g/day)
6. Duration: Usually 5–10 days for moderate infections

When Not to Use (GETOFIN 500MG IV INJECTION):

Do not use if you have:

1. Hypersensitivity to ceftriaxone, other cephalosporins, or penicillins (cross-reactivity possible)
2. History of anaphylaxis to beta-lactam antibiotics
3. Neonates with hyperbilirubinemia (risk of bilirubin displacement)
4. Concomitant administration of calcium-containing IV solutions in neonates (risk of precipitation)

Side Effects of (GETOFIN 500MG IV INJECTION):

Common: Diarrhea, nausea, rash, elevated liver enzymes, phlebitis at infusion site.

Rare: Headache, dizziness, blood dyscrasias (e.g., eosinophilia).

Serious (rare):

1. Clostridioides difficile-associated diarrhea (CDAD)
2. Hypersensitivity reactions (anaphylaxis, Stevens-Johnson syndrome)
3. Biliary pseudolithiasis (with prolonged high-dose use)
4. Discontinue and seek immediate medical help if severe diarrhea, blistering rash, jaundice, or dark urine occurs.

Dosage: (GETOFIN 500MG IV INJECTION):

1. Adults: 500mg–2g once daily (based on infection type and severity)
2. Children: 25–100 mg/kg/day in 1–2 divided doses (max 4g/day)
3. Renal/hepatic impairment: Usually no dose adjustment needed
4. Meningitis or sepsis: Higher doses (1–2g twice daily) required—500mg may be insufficient

Who It’s For (GETOFIN 500MG IV INJECTION):

Adults and children with moderate bacterial infections requiring IV therapy, especially in outpatient, emergency, or step-down hospital settings. Not for life-threatening infections like meningitis or septic shock as monotherapy.

Warnings & Precautions:

1. Avoid in patients with known cephalosporin allergy
2. Monitor for C. difficile diarrhea during or after treatment
3. Do not mix with calcium-containing solutions (especially in neonates)
4. Cross-reactivity with penicillins: ~5–10% risk in allergic individuals

Drug Interactions:

1. Aminoglycosides: Additive nephrotoxicity—monitor renal function
2. Loop diuretics (e.g., furosemide): May increase nephrotoxicity risk
3. Oral anticoagulants: Ceftriaxone may enhance anticoagulant effect (monitor INR)
4. Always inform your doctor about all medications.

Additional Information:

Store unreconstituted vials below 25°C. After reconstitution and dilution, use immediately or within 24 hours if stored at room temperature. Keep out of reach of children. For clinical use only. Available by prescription in Pakistan.