Product Information:

GETOFIN 500mg IM Injection contains Ceftriaxone 500mg as the active ingredient. Ceftriaxone is a third-generation cephalosporin antibiotic with broad-spectrum activity against Gram-positive and Gram-negative bacteria, including Streptococcus pneumoniae, Haemophilus influenzae, Neisseria gonorrhoeae, Escherichia coli, Klebsiella spp., and Proteus mirabilis. It works by inhibiting bacterial cell wall synthesis, leading to bacterial cell death.

This intermediate-strength formulation is commonly used for moderate infections, pediatric dosing, or as a single-dose treatment for uncomplicated gonorrhea in settings where higher doses are not required.

⚠️ Note: Despite the brand name "GETOFIN," this product is not related to finasteride or antifungal agents—it is a cephalosporin antibiotic.

Uses of (GETOFIN 500MG IM INJECTION):

1. Uncomplicated gonorrhea (single-dose therapy)
2. Moderate skin and soft tissue infections
3. Community-acquired pneumonia (outpatient or mild inpatient cases)
4. Urinary tract infections (uncomplicated to moderately complicated)
5. Pediatric bacterial infections (dose adjusted by weight)
6. Surgical prophylaxis in moderate-risk procedures

Key Benefits of (GETOFIN 500MG IM INJECTION):

1. Broad-spectrum coverage against common community and hospital pathogens
2. Long half-life (~8 hours) allows once-daily dosing
3. Good tissue penetration (lungs, skin, genitourinary tract)
4. Suitable for outpatient or clinic-based parenteral therapy
5. Dual excretion (renal and biliary)—safe in mild renal or hepatic impairment

How To Use (GETOFIN 500MG IM INJECTION):

1. Administered intramuscularly (IM) by a healthcare professional.
2. Reconstitute with 1% lidocaine (without epinephrine) to reduce injection site pain.
3. Inject deep into a large muscle (e.g., gluteus maximus or vastus lateralis).
4. Do not administer IV unless specifically reconstituted for IV use—this formulation is labeled for IM use.
5. Typical adult dose:
6. Gonorrhea: Single 500mg IM dose (especially if >150 kg or pharyngeal infection)
7. Other infections: 500mg–1g once daily
8. Pediatric dose: Based on body weight (typically 25–50 mg/kg/day)

When Not to Use (GETOFIN 500MG IM INJECTION):

Do not use if you have:

1. Hypersensitivity to ceftriaxone, other cephalosporins, or penicillins (cross-reactivity possible)
2. History of anaphylaxis to beta-lactam antibiotics
3. Neonates with hyperbilirubinemia (risk of bilirubin displacement)
4. Concomitant use of calcium-containing IV solutions in neonates

Side Effects of (GETOFIN 500MG IM INJECTION):

Common: Pain or induration at injection site, diarrhea, nausea, rash, headache.

Rare: Dizziness, vaginitis, elevated liver enzymes, eosinophilia.

Serious (rare):

1. Clostridioides difficile-associated diarrhea (CDAD)
2. Hypersensitivity reactions (anaphylaxis, Stevens-Johnson syndrome)
3. Biliary pseudolithiasis (with prolonged high-dose use)
4. Discontinue and seek immediate medical help if severe diarrhea, blistering rash, breathing difficulty, or jaundice occurs.

Dosage: (GETOFIN 500MG IM INJECTION):

1. Uncomplicated gonorrhea: Single 500mg IM dose (per updated WHO/CDC guidelines for higher efficacy)
2. Other infections: 500mg–2g once daily based on severity
3. Children: 25–100 mg/kg/day in 1–2 divided doses (max 4g/day)
4. Duration: Typically 3–7 days for mild to moderate infections

Who It’s For (GETOFIN 500MG IM INJECTION):

Adults and children with moderate bacterial infections suitable for outpatient management, including sexually transmitted infections, respiratory, urinary, or skin infections.

Warnings & Precautions:

1. Avoid in patients with known cephalosporin allergy
2. Monitor for C. difficile diarrhea during or after treatment
3. Do not mix with calcium-containing solutions
4. Use caution in penicillin-allergic patients (~5–10% cross-reactivity risk)

Drug Interactions:

1. Aminoglycosides: Additive nephrotoxicity—monitor renal function
2. Oral anticoagulants (e.g., warfarin): Ceftriaxone may enhance anticoagulant effect—monitor INR
3. Always inform your doctor about all medications and supplements.

Additional Information:

Store unreconstituted vials below 25°C in a dry place. Reconstituted solution should be used immediately. Keep out of reach of children. For clinical or outpatient use only. Available by prescription in Pakistan.