Product Information:

GETOFIN 250mg IM Injection contains Ceftriaxone 250mg as the active ingredient. Ceftriaxone is a third-generation cephalosporin antibiotic with broad-spectrum activity against Gram-positive and Gram-negative bacteria, including Streptococcus pneumoniae, Haemophilus influenzae, Neisseria gonorrhoeae, Escherichia coli, and Klebsiella spp. It works by inhibiting bacterial cell wall synthesis, leading to bacterial cell death.

This lower-strength formulation is commonly used for mild to moderate infections, pediatric dosing, or single-dose treatment of uncomplicated gonorrhea.

⚠️ Note: Despite the brand name "GETOFIN," this product is not related to finasteride or antifungals—it is a cephalosporin antibiotic.

Uses of (GETOFIN 250MG IM INJECTION):

1. Uncomplicated gonorrhea (single-dose therapy)
2. Mild to moderate skin and soft tissue infections
3. Pediatric bacterial infections (dose adjusted by weight)
4. Outpatient treatment of community-acquired pneumonia (in selected cases)
5. Surgical prophylaxis in low-risk procedures

Key Benefits of (GETOFIN 250MG IM INJECTION):

1. Broad-spectrum coverage with once-daily dosing potential
2. Long half-life (~8 hours) allows flexible administration
3. Effective against common community pathogens
4. Suitable for outpatient or clinic-based use
5. Good tissue penetration (lungs, skin, genitourinary tract)

How To Use (GETOFIN 250MG IM INJECTION):

1. Administered intramuscularly (IM) by a healthcare professional.
2. Reconstitute with 1% lidocaine (without epinephrine) to reduce injection pain.
3. Inject deep into a large muscle (e.g., gluteus or thigh).
4. Do not administer IV unless reconstituted appropriately—this formulation is labeled for IM use.
5. Typical adult dose:
6. Gonorrhea: Single 250mg IM dose
7. Other infections: May be given once daily; total daily dose adjusted based on severity
8. Pediatric dose: Based on body weight (typically 25–50 mg/kg/day)

When Not to Use (GETOFIN 250MG IM INJECTION):

Do not use if you have:

1. Hypersensitivity to ceftriaxone, other cephalosporins, or penicillins (cross-reactivity possible)
2. History of anaphylaxis to beta-lactam antibiotics
3. Neonates with hyperbilirubinemia (risk of bilirubin displacement)
4. Concomitant use of calcium-containing IV solutions in neonates

Side Effects of (GETOFIN 250MG IM INJECTION):

Common: Pain at injection site, diarrhea, nausea, rash, headache.

Rare: Dizziness, vaginitis, elevated liver enzymes.

Serious (rare):

1. Clostridioides difficile-associated diarrhea (CDAD)
2. Hypersensitivity reactions (anaphylaxis, Stevens-Johnson syndrome)
3. Biliary pseudolithiasis (with prolonged high-dose use)
4. Discontinue and seek immediate help if severe diarrhea, blistering rash, or breathing difficulty occurs.

Dosage: (GETOFIN 250MG IM INJECTION):

1. Uncomplicated gonorrhea: Single 250mg IM dose
2. Other infections: 250mg–1g once daily (based on clinical response)
3. Children: Dose calculated by weight (max 4g/day)
4. Duration: Typically 3–7 days for mild infections

Who It’s For (GETOFIN 250MG IM INJECTION):

Adults and children with mild to moderate bacterial infections suitable for outpatient management. Commonly used in clinics, emergency departments, or for single-dose STD treatment.

Warnings & Precautions:

1. Avoid in patients with known cephalosporin allergy
2. Monitor for C. difficile diarrhea during or after treatment
3. Do not mix with calcium-containing solutions
4. Use caution in penicillin-allergic patients (~5–10% cross-reactivity risk)

Drug Interactions:

1. Aminoglycosides: Additive nephrotoxicity
2. Oral anticoagulants: May enhance anticoagulant effect (monitor INR)
3. Always inform your doctor about all medications.

Additional Information:

Store unreconstituted vials below 25°C. Reconstituted solution should be used immediately. Keep out of reach of children. For clinical use only. Available by prescription in Pakistan.