Product Information:

GETFIL 50mg Tablets contain Gliclazide 50mg, a second-generation sulfonylurea oral antidiabetic agent. It works primarily by stimulating insulin secretion from pancreatic beta cells in response to glucose. Gliclazide also exhibits mild antioxidant and antiplatelet properties, which may contribute to reduced microvascular complications in type 2 diabetes.

The 50mg strength is commonly used as a maintenance or intermediate dose for patients requiring more glycemic control than lower doses provide.

⚠️ Note: Despite the name “GETFIL,” this product is not filgrastim (which is an injectable biologic dosed in micrograms). The naming likely follows local branding conventions in Pakistan, where “GET” may derive from “Gliclazide.”

Uses of (GETFIL 50MG TAB):

1. Management of type 2 diabetes mellitus in adults
2. As monotherapy when lifestyle modifications are insufficient
3. In combination with metformin, SGLT2 inhibitors, or other non-insulin agents

Key Benefits of (GETFIL 50MG TAB):

1. Once- or twice-daily dosing for flexible regimens
2. Lower risk of prolonged hypoglycemia compared to older sulfonylureas (e.g., glibenclamide)
3. Potential vascular protective effects due to antioxidant activity
4. Cost-effective and widely available

How To Use (GETFIL 50MG TAB):

1. Take with breakfast or the first main meal of the day to reduce hypoglycemia risk.
2. Swallow whole with water—do not crush or chew.
3. Typical adult dosage:
4. Starting dose: 40–80mg once daily
5. Maintenance: 50–160mg once or twice daily, based on glycemic response
6. Do not skip meals while on this medication.

When Not to Use (GETFIL 50MG TAB):

Do not use if you have:

1. Type 1 diabetes mellitus
2. Diabetic ketoacidosis
3. Severe renal impairment (eGFR <30 mL/min)
4. Severe hepatic impairment
5. Hypersensitivity to gliclazide or other sulfonylureas

Side Effects of (GETFIL 50MG TAB):

Common:

1. Hypoglycemia (sweating, dizziness, tremor, palpitations)—especially if meals are delayed or skipped
2. Nausea, abdominal discomfort
3. Weight gain (mild to moderate)

Less common:

1. Skin rash, photosensitivity
2. Elevated liver enzymes
3. Transient visual disturbances (rare)

Serious (rare):

1. Severe hypoglycemia (confusion, seizures, loss of consciousness)—requires emergency glucose
2. Hepatotoxicity (jaundice, dark urine, fatigue)
3. Blood dyscrasias (e.g., leukopenia, thrombocytopenia)—very rare
4. Seek medical help if severe symptoms occur.

Dosage: (GETFIL 50MG TAB):

1. Adults: Typically 50–160mg once or twice daily
2. Maximum daily dose: 160mg
3. Elderly or mild renal impairment: Start at 40mg once daily; monitor closely

Who It’s For (GETFIL 50MG TAB):

Adults with type 2 diabetes who require reliable insulin secretagogue therapy and can adhere to regular meal schedules to mitigate hypoglycemia risk.

Warnings & Precautions:

1. Avoid alcohol—increases hypoglycemia risk and may cause disulfiram-like reaction
2. Monitor blood glucose regularly, especially during dose changes
3. Use caution in elderly patients (higher hypoglycemia risk)
4. Educate patients on hypoglycemia recognition and management
5. Discontinue before iodinated contrast procedures if eGFR is borderline

Drug Interactions:

1. Beta-blockers: May mask tachycardia during hypoglycemia
2. NSAIDs, salicylates, sulfonamides: ↑ Risk of hypoglycemia
3. Rifampin: ↓ Gliclazide efficacy—monitor blood glucose
4. Alcohol: May cause flushing, nausea, or severe hypoglycemia
5. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.