Product Information:

GETFIL 100mg Tablets contain Gliclazide 100mg, a second-generation sulfonylurea oral antidiabetic agent. It works by stimulating insulin release from pancreatic beta cells in a glucose-dependent manner. Gliclazide also possesses mild antioxidant and antiplatelet properties, which may contribute to vascular protection in patients with type 2 diabetes.

The 100mg strength is commonly used as a higher maintenance dose for patients requiring intensified glycemic control who are already tolerating lower doses.

⚠️ Note: Despite the name “GETFIL,” this product is not filgrastim (which is an injectable biologic). The name likely follows local Pakistani branding, where “GET” is derived from “Gliclazide.”

Uses of (GETFIL 100MG TAB):

1. Management of type 2 diabetes mellitus in adults
2. As monotherapy or in combination with metformin, SGLT2 inhibitors, or other non-insulin agents
3. For patients uncontrolled on lower doses of gliclazide (e.g., 50–80mg)

Key Benefits of (GETFIL 100MG TAB):

1. Once- or twice-daily dosing for flexible regimens
2. Lower risk of prolonged hypoglycemia compared to older sulfonylureas (e.g., glibenclamide)
3. Potential microvascular protective effects
4. Cost-effective option for long-term diabetes management

How To Use (GETFIL 100MG TAB):

1. Take with breakfast or the first main meal of the day to reduce hypoglycemia risk.
2. Swallow whole with water—do not crush or chew.
3. Typical adult dosage:
4. Maintenance: 100–160mg once or twice daily, based on glycemic response
5. Maximum daily dose: 160mg
6. Do not skip meals while on this medication.

When Not to Use (GETFIL 100MG TAB):

Do not use if you have:

1. Type 1 diabetes mellitus
2. Diabetic ketoacidosis
3. Severe renal impairment (eGFR <30 mL/min)
4. Severe hepatic impairment
5. Hypersensitivity to gliclazide or other sulfonylureas

Side Effects of (GETFIL 100MG TAB):

Common:

1. Hypoglycemia (sweating, dizziness, tremor, palpitations)—more likely at higher doses
2. Nausea, abdominal discomfort
3. Weight gain (mild to moderate)

Less common:

1. Skin rash, photosensitivity
2. Elevated liver enzymes
3. Transient visual disturbances

Serious (rare):

1. Severe hypoglycemia (confusion, seizures, loss of consciousness)—requires emergency glucose
2. Hepatotoxicity (jaundice, dark urine, fatigue)
3. Blood dyscrasias (e.g., agranulocytosis, thrombocytopenia)—very rare
4. Seek immediate medical help if severe symptoms occur.

Dosage: (GETFIL 100MG TAB):

1. Adults: Typically 100–160mg once or twice daily
2. Maximum daily dose: 160mg
3. Elderly or mild-to-moderate renal impairment: Use with caution; avoid >80mg/day unless closely monitored

Who It’s For (GETFIL 100MG TAB):

Adults with type 2 diabetes who require stronger insulin secretagogue therapy and can maintain regular meal schedules to mitigate hypoglycemia risk.

Warnings & Precautions:

1. Avoid alcohol—increases hypoglycemia risk and may cause disulfiram-like reaction (flushing, nausea)
2. Monitor blood glucose regularly, especially during dose escalation
3. Use extra caution in elderly or malnourished patients (higher hypoglycemia risk)
4. Educate patients on hypoglycemia recognition and emergency management
5. Discontinue before iodinated contrast procedures if renal function is impaired

Drug Interactions:

1. Beta-blockers: May mask tachycardia during hypoglycemia
2. NSAIDs, salicylates, sulfonamides: ↑ Risk of hypoglycemia
3. Rifampin: ↓ Gliclazide efficacy—monitor blood glucose closely
4. Alcohol: May potentiate hypoglycemia or cause adverse reactions
5. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.