Product Information:

GABIX 300mg Capsules contain Pregabalin 300mg as the active ingredient. Pregabalin is a gamma-aminobutyric acid (GABA) analog that binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This reduces the release of excitatory neurotransmitters (e.g., glutamate, substance P, noradrenaline), thereby modulating neuropathic pain, seizure activity, and anxiety.

This is the highest standard strength of immediate-release pregabalin, used for severe or treatment-resistant conditions requiring intensified therapy.

Uses of (GABIX 300MG CAPSULES):

1. Management of severe neuropathic pain (e.g., diabetic neuropathy, postherpetic neuralgia, spinal cord injury)
2. Adjunctive therapy in refractory partial-onset seizures in adults with epilepsy
3. Off-label treatment of generalized anxiety disorder (GAD) in select, treatment-resistant cases
4. Symptomatic relief in fibromyalgia (off-label use)

Key Benefits of (GABIX 300MG CAPSULES):

1. High potency for patients unresponsive to lower doses
2. Flexible dosing (typically once or twice daily) based on clinical need
3. Rapid and sustained symptom control in severe conditions
4. No hepatic metabolism—low risk of CYP450-mediated drug interactions

How To Use (GABIX 300MG CAPSULES):

1. Take as prescribed, usually once or twice daily (e.g., morning and/or evening).
2. Swallow whole with water—do not crush, chew, or open.
3. Can be taken with or without food, but maintain consistency.
4. Do not stop abruptly—taper gradually under medical supervision to avoid withdrawal symptoms (insomnia, nausea, headache, seizures, or rebound anxiety).

When Not to Use (GABIX 300MG CAPSULES):

Do not use if you have:

1. Hypersensitivity to pregabalin or any excipients
2. History of angioedema with pregabalin
3. Severe renal impairment (CrCl <30 mL/min) without dose adjustment
4. Pregnancy or breastfeeding (unless clearly needed after thorough risk-benefit assessment)

Side Effects of (GABIX 300MG CAPSULES):

Common: Dizziness, somnolence (drowsiness), dry mouth, peripheral edema (swelling in legs/feet), weight gain, blurred vision, fatigue, difficulty concentrating.

Serious (rare but more likely at high doses):

1. Angioedema (facial, lip, tongue, or throat swelling—seek emergency care)
2. Suicidal thoughts or behavior (monitor mood closely)
3. Rhabdomyolysis (muscle pain, weakness, dark urine)
4. Worsening heart failure due to fluid retention
5. Severe drowsiness or respiratory depression (especially when combined with CNS depressants)
6. Discontinue and seek immediate medical help if serious reactions occur.

Dosage: (GABIX 300MG CAPSULES):

1. Neuropathic pain: 300mg once daily or 150–300mg twice daily (max 600mg/day)
2. Epilepsy: 300–600mg/day in 2–3 divided doses
3. Renal impairment: Dose must be reduced (e.g., 300mg every other day if CrCl <30 mL/min)
4. Elderly: Use with caution; may require lower total daily dose

Who It’s For (GABIX 300MG CAPSULES):

Adults with severe, treatment-resistant neuropathic pain or epilepsy who have failed lower doses of pregabalin. Not for acute pain, mild symptoms, or children unless under specialist care.

Warnings & Precautions:

1. May significantly impair driving or operating machinery—avoid until effects are known
2. Monitor for weight gain, edema, cognitive effects, and mood changes
3. Use cautiously in patients with heart failure, diabetes, or history of substance abuse
4. High potential for misuse or dependence—prescribe only when benefits outweigh risks

Drug Interactions:

1. CNS depressants (opioids, benzodiazepines, alcohol): Additive sedation and life-threatening respiratory depression
2. Thiazolidinediones (e.g., pioglitazone, rosiglitazone): Increased risk of fluid retention and heart failure
3. ACE inhibitors: May increase risk of angioedema
4. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date on the blister pack. Available by prescription only in Pakistan.