Product Information:

GABIX 100mg Capsules contain Pregabalin 100mg as the active ingredient. Pregabalin is a gamma-aminobutyric acid (GABA) analog that binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This action reduces the release of excitatory neurotransmitters (e.g., glutamate, substance P, noradrenaline), thereby modulating neuropathic pain, seizure activity, and anxiety.

This strength is commonly used for moderate symptoms and offers a balance between efficacy and tolerability in adults.

Uses of (GABIX 100MG CAPSULES):

1. Management of peripheral and central neuropathic pain (e.g., diabetic neuropathy, postherpetic neuralgia, spinal cord injury)
2. Adjunctive therapy in partial-onset seizures in adults with epilepsy
3. Off-label treatment of generalized anxiety disorder (GAD) (used in clinical practice in Pakistan)
4. Symptomatic relief in fibromyalgia (off-label)

Key Benefits of (GABIX 100MG CAPSULES):

1. Effective for chronic nerve-related pain unresponsive to conventional analgesics
2. Flexible dosing (typically twice daily) for individualized therapy
3. Rapid onset of symptom relief (within days to weeks)
4. No metabolism by liver CYP450 enzymes—low risk of drug interactions

How To Use (GABIX 100MG CAPSULES):

1. Take as prescribed, usually twice daily (e.g., morning and evening).
2. Swallow whole with water—do not crush, chew, or open.
3. Can be taken with or without food, but take consistently the same way each day.
4. Do not stop abruptly—taper gradually under medical supervision to avoid withdrawal symptoms (insomnia, headache, nausea, or seizures).

When Not to Use (GABIX 100MG CAPSULES):

Do not use if you have:

1. Hypersensitivity to pregabalin or any excipients
2. History of angioedema with pregabalin
3. Severe renal impairment without dose adjustment
4. Pregnancy or breastfeeding (unless clearly needed after risk-benefit assessment)

Side Effects of (GABIX 100MG CAPSULES):

Common: Dizziness, somnolence (drowsiness), dry mouth, peripheral edema (swelling in legs/feet), weight gain, blurred vision, difficulty concentrating.

Serious (rare):

1. Angioedema (facial, lip, or throat swelling—seek emergency care)
2. Suicidal thoughts or behavior (monitor mood changes closely)
3. Rhabdomyolysis (muscle pain, weakness, dark urine)
4. Worsening heart failure due to fluid retention
5. Discontinue and seek medical help if severe reactions occur.

Dosage: (GABIX 100MG CAPSULES):

1. Neuropathic pain: Starting dose 75–100mg twice daily; may increase based on response
2. Epilepsy: 100–150mg two or three times daily (max 600mg/day)
3. Renal impairment: Dose must be reduced based on creatinine clearance
4. Elderly: Start at lower doses due to reduced kidney function

Who It’s For (GABIX 100MG CAPSULES):

Adults with neuropathic pain, epilepsy, or anxiety disorders requiring effective neuromodulatory therapy. Not for acute pain or children unless specifically indicated.

Warnings & Precautions:

1. May impair driving or operating machinery—avoid until effects are known
2. Monitor for weight gain, edema, and mood changes
3. Use cautiously in patients with heart failure, diabetes, or history of substance abuse
4. Risk of misuse or dependence in individuals with substance use history

Drug Interactions:

1. CNS depressants (opioids, benzodiazepines, alcohol): Additive sedation and respiratory depression
2. Thiazolidinediones (e.g., pioglitazone): Increased risk of fluid retention and heart failure
3. ACE inhibitors: May increase risk of angioedema
4. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date on the blister pack. Available by prescription in Pakistan.