Product Information:

GABICA 75mg Capsules contain Pregabalin 75mg as the active ingredient. Pregabalin is a gamma-aminobutyric acid (GABA) analog that binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This reduces the release of excitatory neurotransmitters (e.g., glutamate, substance P, noradrenaline), thereby modulating neuropathic pain, seizure activity, and anxiety.

This intermediate strength is commonly used as a maintenance dose or for patients requiring once- or twice-daily dosing with good tolerability.

Uses of (GABICA 75MG CAPSULES):

1. Management of moderate neuropathic pain (e.g., diabetic neuropathy, postherpetic neuralgia)
2. Adjunctive therapy in partial-onset seizures in adults with epilepsy
3. Off-label treatment of generalized anxiety disorder (GAD)
4. Step-up from lower doses (e.g., 25mg or 50mg) based on clinical response

Key Benefits of (GABICA 75MG CAPSULES):

1. Effective balance between efficacy and tolerability
2. Enables simplified dosing (e.g., twice daily instead of three times)
3. Suitable for long-term maintenance therapy
4. Lower pill burden compared to lower-strength formulations

How To Use (GABICA 75MG CAPSULES):

1. Take as prescribed, typically once or twice daily (e.g., morning and evening).
2. Swallow whole with water—do not crush, chew, or open.
3. Can be taken with or without food, but maintain consistency.
4. Do not stop abruptly—taper gradually under medical supervision to avoid withdrawal symptoms (insomnia, headache, nausea, or seizures).

When Not to Use (GABICA 75MG CAPSULES):

Do not use if you have:

1. Hypersensitivity to pregabalin or any excipients
2. History of angioedema with pregabalin
3. Severe renal impairment without dose adjustment
4. Pregnancy or breastfeeding (unless clearly needed after risk-benefit assessment)

Side Effects of (GABICA 75MG CAPSULES):

Common: Dizziness, drowsiness, dry mouth, mild peripheral edema (swelling in legs/feet), blurred vision, weight gain.

Rare: Difficulty concentrating, mood changes, fatigue.

Serious (rare):

1. Angioedema (facial, lip, or throat swelling—seek emergency care)
2. Suicidal thoughts or behavior (monitor for new or worsening depression)
3. Discontinue and seek medical help if severe reactions occur.

Dosage: (GABICA 75MG CAPSULES):

1. Neuropathic pain: 75mg twice daily (may increase to 150mg BID if needed)
2. Epilepsy: 75–150mg twice or three times daily (max 600mg/day)
3. Renal impairment: Reduce frequency (e.g., once daily if CrCl 30–59 mL/min)
4. Elderly: Start at 75mg once or twice daily; monitor for sedation and falls

Who It’s For (GABICA 75MG CAPSULES):

Adults with moderate neuropathic pain, epilepsy, or anxiety disorders who have responded to initial titration and require a stable maintenance dose. Ideal for those seeking reduced dosing frequency.

Warnings & Precautions:

1. May impair driving or operating machinery—avoid until effects are known
2. Monitor for weight gain, fluid retention, and mood changes
3. Use cautiously in patients with heart failure or history of substance abuse
4. Risk of misuse exists—prescribe responsibly

Drug Interactions:

1. CNS depressants (alcohol, opioids, benzodiazepines): Additive sedation and respiratory depression
2. ACE inhibitors: Possible increased risk of angioedema
3. Thiazolidinediones (e.g., pioglitazone): May worsen fluid retention
4. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date on the blister pack. Available by prescription in Pakistan.