Product Information:

GABICA 50mg Capsules contain Pregabalin 50mg as the active ingredient. Pregabalin is a gamma-aminobutyric acid (GABA) analog that binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This reduces the release of excitatory neurotransmitters (e.g., glutamate, substance P, noradrenaline), helping to control neuropathic pain, seizures, and anxiety.

This intermediate-low strength is commonly used for dose titration, mild to moderate symptoms, or patients requiring flexible dosing adjustments.

Uses of (GABICA 50MG CAPSULES):

1. Management of mild to moderate neuropathic pain (e.g., diabetic neuropathy, postherpetic neuralgia)
2. Adjunctive therapy in partial-onset seizures in adults
3. Off-label treatment of generalized anxiety disorder (GAD)
4. Step-up therapy from lower doses (e.g., 25mg) based on response

Key Benefits of (GABICA 50MG CAPSULES):

1. Balanced potency for effective symptom control with reduced side effects
2. Ideal for dose escalation during initial therapy
3. Suitable for patients with moderate renal function
4. Flexible dosing (typically two to three times daily)

How To Use (GABICA 50MG CAPSULES):

1. Take as prescribed, usually two or three times daily (e.g., morning and evening, or TDS).
2. Swallow whole with water—do not crush, chew, or open.
3. Can be taken with or without food, but take consistently the same way each day.
4. Do not stop abruptly—taper gradually under medical supervision to avoid withdrawal symptoms (insomnia, headache, nausea, or seizures).

When Not to Use (GABICA 50MG CAPSULES):

Do not use if you have:

1. Hypersensitivity to pregabalin or any excipients
2. History of angioedema with pregabalin
3. Severe renal impairment without dose adjustment
4. Pregnancy or breastfeeding (unless clearly needed after risk-benefit assessment)

Side Effects of (GABICA 50MG CAPSULES):

Common: Dizziness, drowsiness, dry mouth, mild peripheral edema, headache, blurred vision.

Rare: Weight gain, difficulty concentrating, mood changes.

Serious (very rare at this dose):

1. Angioedema (facial or throat swelling)
2. Suicidal thoughts (monitor for new or worsening depression)
3. Discontinue and seek medical help if severe reactions occur.

Dosage: (GABICA 50MG CAPSULES):

1. Neuropathic pain: Starting dose 50mg two or three times daily; may increase to 100–150mg TDS based on response
2. Epilepsy: 50–100mg two or three times daily (max 600mg/day)
3. Renal impairment: Reduce frequency (e.g., twice daily if CrCl 30–59 mL/min)
4. Elderly: Start at 50mg BID; monitor for sedation and falls

Who It’s For (GABICA 50MG CAPSULES):

Adults with mild to moderate neuropathic pain, epilepsy, or anxiety who require a balanced starting or maintenance dose. Commonly used during dose optimization.

Warnings & Precautions:

1. May impair driving or operating machinery—avoid until individual response is known
2. Monitor for weight gain, edema, and mood changes
3. Use cautiously in patients with heart failure or history of substance abuse
4. Risk of misuse exists—prescribe responsibly

Drug Interactions:

1. CNS depressants (alcohol, opioids, benzodiazepines): Additive sedation and respiratory depression
2. ACE inhibitors: Possible increased risk of angioedema
3. Pioglitazone or rosiglitazone: May worsen fluid retention
4. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date on the blister pack. Available by prescription in Pakistan.