Product Information:

GABICA 25mg Capsules contain Pregabalin 25mg as the active ingredient. Pregabalin is a gamma-aminobutyric acid (GABA) analog that binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This reduces the release of excitatory neurotransmitters (e.g., glutamate, substance P, noradrenaline), helping to modulate nerve pain, seizure activity, and anxiety.

This low-strength formulation is primarily used for dose titration, elderly patients, or individuals with mild symptoms or renal impairment.

Uses of (GABICA 25MG CAPSULES):

1. Initial treatment or dose titration in neuropathic pain (e.g., diabetic neuropathy, postherpetic neuralgia)
2. Management of partial-onset seizures in sensitive or elderly patients
3. Off-label use in generalized anxiety disorder (GAD) at low doses
4. Patients with mild renal impairment requiring reduced dosing

Key Benefits of (GABICA 25MG CAPSULES):

1. Allows gradual dose escalation to improve tolerability
2. Reduces risk of side effects (dizziness, drowsiness) in sensitive individuals
3. Suitable for elderly patients or those with kidney dysfunction
4. Flexible dosing for personalized therapy

How To Use (GABICA 25MG CAPSULES):

1. Take as prescribed, usually two or three times daily (e.g., morning, afternoon, and/or evening).
2. Swallow whole with water—do not crush, chew, or open.
3. Can be taken with or without food, but take consistently the same way each day.
4. Do not stop abruptly—taper gradually under medical supervision to avoid withdrawal symptoms (insomnia, headache, nausea, or seizures).

When Not to Use (GABICA 25MG CAPSULES):

Do not use if you have:

1. Hypersensitivity to pregabalin or any excipients
2. History of angioedema with pregabalin
3. Pregnancy or breastfeeding (unless clearly needed after risk-benefit assessment)

Side Effects of (GABICA 25MG CAPSULES):

Common (less frequent at this dose): Mild dizziness, slight drowsiness, dry mouth, or headache.

Serious (very rare at low dose):

1. Angioedema (facial or throat swelling)
2. Mood changes or suicidal thoughts
3. Peripheral edema (swelling in legs/feet)
4. Discontinue and seek medical help if severe reactions occur.

Dosage: (GABICA 25MG CAPSULES):

1. Starting dose for neuropathic pain or epilepsy: 25mg two or three times daily
2. May be increased gradually (e.g., to 50–75mg TDS) based on response and tolerability
3. Renal impairment: Ideal starting strength; adjust frequency based on creatinine clearance
4. Elderly: Preferred initial dose due to reduced kidney function

Who It’s For (GABICA 25MG CAPSULES):

1. Elderly patients
2. Individuals initiating pregabalin therapy
3. Patients with mild symptoms or high sensitivity to CNS medications
4. Those with mild to moderate renal impairment

Warnings & Precautions:

1. May still cause drowsiness—avoid driving until effects are known
2. Monitor for mood changes, even at low doses
3. Use cautiously in patients with heart failure (risk of fluid retention)
4. Risk of misuse is low at this dose but remains possible in susceptible individuals

Drug Interactions:

1. CNS depressants (alcohol, opioids, benzodiazepines): Additive sedation
2. ACE inhibitors: Possible increased risk of angioedema
3. Thiazolidinediones (e.g., pioglitazone): May worsen fluid retention
4. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date on the blister pack. Available by prescription in Pakistan.