Product Information:

GABICA 150mg Capsules contain Pregabalin 150mg as the active ingredient. Pregabalin is a gamma-aminobutyric acid (GABA) analog that binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This reduces the release of excitatory neurotransmitters (e.g., glutamate, substance P, noradrenaline), thereby modulating neuropathic pain, seizure activity, and anxiety.

This higher-strength formulation is used for moderate to severe conditions requiring intensified therapy or less frequent dosing.

Uses of (GABICA 150MG CAPSULES):

1. Management of moderate to severe neuropathic pain (diabetic neuropathy, postherpetic neuralgia, spinal cord injury)
2. Adjunctive treatment of partial-onset seizures in adults with epilepsy
3. Treatment of generalized anxiety disorder (GAD) (off-label use in Pakistan)
4. Symptomatic relief in fibromyalgia (off-label)

Key Benefits of (GABICA 150MG CAPSULES):

1. Higher dose allows for simplified dosing regimen (e.g., twice daily instead of three times)
2. Effective for patients unresponsive to lower doses
3. Rapid onset of action for pain and anxiety symptoms
4. No hepatic metabolism—low risk of drug interactions via CYP450 enzymes

How To Use (GABICA 150MG CAPSULES):

1. Take as prescribed, typically once or twice daily (e.g., morning and/or evening).
2. Swallow whole with water—do not crush, chew, or open.
3. Can be taken with or without food, but maintain consistency.
4. Do not stop abruptly—taper gradually under medical supervision to avoid withdrawal (insomnia, nausea, headache, seizures).

When Not to Use (GABICA 150MG CAPSULES):

Do not use if you have:

1. Hypersensitivity to pregabalin or any excipients
2. History of angioedema with pregabalin
3. Severe renal impairment without dose adjustment
4. Pregnancy or breastfeeding (unless clearly needed after risk-benefit assessment)

Side Effects of (GABICA 150MG CAPSULES):

Common: Dizziness, drowsiness, dry mouth, peripheral edema (swelling in legs/feet), weight gain, blurred vision, difficulty concentrating.

Serious (rare):

1. Angioedema (facial, lip, or throat swelling—seek emergency care)
2. Suicidal ideation or behavior (monitor mood changes closely)
3. Rhabdomyolysis (muscle pain, weakness, dark urine)
4. Worsening heart failure due to fluid retention
5. Discontinue and seek immediate medical help if severe reactions occur.

Dosage: (GABICA 150MG CAPSULES):

1. Neuropathic pain: 150mg twice daily (may increase to 300mg/day based on response)
2. Epilepsy: 150–300mg twice daily (max 600mg/day)
3. Renal impairment: Dose must be reduced (e.g., once daily if CrCl <30 mL/min)
4. Elderly: Start at lower doses; monitor for sedation and falls

Who It’s For (GABICA 150MG CAPSULES):

Adults with moderate to severe neuropathic pain, epilepsy, or anxiety disorders who require higher or less frequent dosing. Not for acute pain or children unless specifically directed by a specialist.

Warnings & Precautions:

1. May impair driving or operating machinery—avoid until effects are known
2. Monitor for weight gain, edema, and psychiatric symptoms
3. Use cautiously in patients with heart failure, diabetes, or history of substance abuse
4. Risk of misuse or dependence—prescribe with caution in high-risk individuals

Drug Interactions:

1. CNS depressants (opioids, benzodiazepines, alcohol): Additive sedation and respiratory depression
2. Thiazolidinediones (e.g., pioglitazone): Increased risk of fluid retention and heart failure
3. ACE inhibitors: May increase risk of angioedema
4. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date on the blister pack. Available by prescription in Pakistan.