Product Information:

GABICA 10 0mg Capsules contain Pregabalin 100mg as the active ingredient. Pregabalin is a gamma-aminobutyric acid (GABA) analog that binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This action reduces the release of excitatory neurotransmitters (e.g., glutamate, substance P, noradrenaline), thereby modulating pain signaling and neuronal hyperexcitability.

Uses of (GABICA 100MG CAPSULES):

1. Management of peripheral and central neuropathic pain (e.g., diabetic neuropathy, postherpetic neuralgia, spinal cord injury)
2. Adjunctive therapy in partial-onset seizures in adults with epilepsy
3. Treatment of generalized anxiety disorder (GAD) (approved in some countries; used off-label in Pakistan)
4. Symptomatic relief in fibromyalgia (off-label use)

Key Benefits of (GABICA 100MG CAPSULES):

1. Effective for chronic nerve-related pain unresponsive to conventional analgesics
2. Rapid onset of anxiolytic and analgesic effects (within days to weeks)
3. Low potential for drug interactions (not metabolized by liver CYP450 enzymes)
4. Flexible dosing for titration based on response and tolerability

How To Use (GABICA 100MG CAPSULES):

1. Take as prescribed, usually two or three times daily (e.g., morning and evening).
2. Swallow whole with water—do not crush, chew, or open.
3. Can be taken with or without food, but take consistently the same way each day.
4. Do not stop abruptly—taper gradually under medical supervision to avoid withdrawal symptoms (insomnia, headache, nausea, seizures).

When Not to Use (GABICA 100MG CAPSULES):

Do not use if you have:

1. Hypersensitivity to pregabalin or any excipients
2. History of angioedema with pregabalin
3. Severe renal impairment without dose adjustment
4. Pregnancy or breastfeeding (unless clearly needed—risk-benefit assessment required)

Side Effects of (GABICA 100MG CAPSULES):

Common: Dizziness, somnolence (drowsiness), dry mouth, peripheral edema (swelling in legs/feet), weight gain, blurred vision, difficulty concentrating.

Serious (rare):

1. Angioedema (facial, lip, or throat swelling—seek emergency care)
2. Suicidal thoughts or behavior (monitor mood changes)
3. Rhabdomyolysis (muscle pain, weakness, dark urine)
4. Heart failure exacerbation in predisposed patients (due to fluid retention)
5. Discontinue and seek medical help if severe reactions occur.

Dosage: (GABICA 100MG CAPSULES):

1. Neuropathic pain: Starting dose 75mg twice daily; may increase to 100–150mg twice daily after 3–7 days
2. Epilepsy: 75–150mg twice or three times daily (max 600mg/day)
3. Renal impairment: Dose must be reduced based on creatinine clearance
4. Elderly: Start at lower doses due to reduced kidney function

Who It’s For (GABICA 100MG CAPSULES):

Adults with neuropathic pain, epilepsy, or anxiety disorders requiring neuromodulatory therapy. Not for acute pain or children unless specifically indicated.

Warnings & Precautions:

1. May impair driving or operating machinery—avoid until effects are known
2. Monitor for weight gain, edema, and mood changes
3. Use cautiously in patients with heart failure or diabetes
4. Risk of misuse or dependence in individuals with substance use history

Drug Interactions:

1. CNS depressants (opioids, benzodiazepines, alcohol): Additive sedation and respiratory depression
2. Thiazolidinediones (e.g., pioglitazone): Increased risk of fluid retention and heart failure
3. ACE inhibitors: May increase risk of angioedema
4. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date on the blister pack. Available by prescription in Pakistan.