Product Information:

FEXET 180mg Tablets contain Fexofenadine Hydrochloride 180mg, a second-generation antihistamine used for the relief of symptoms associated with allergic conditions. Fexofenadine is a selective peripheral H1-receptor antagonist that does not significantly cross the blood-brain barrier, making it non-sedating in most individuals. This higher-strength formulation is primarily indicated for chronic idiopathic urticaria and provides extended symptom control with once-daily dosing.

Uses of (FEXET 180MG TABLETS):

1. Management of chronic idiopathic urticaria (hives): reduces itching, redness, and wheal formation
2. Symptomatic treatment of seasonal allergic rhinitis (hay fever) in adults requiring stronger or longer-lasting relief
3. Relief from persistent allergic skin reactions and pruritus

Key Benefits of (FEXET 180MG TABLETS):

1. Non-sedating—minimal drowsiness compared to first-generation antihistamines
2. Once-daily dosing for improved adherence
3. Long duration of action—up to 24 hours
4. No significant cardiac toxicity (unlike older antihistamines like terfenadine)
5. Safe for daily use during allergy seasons or chronic hives

How To Use (FEXET 180MG TABLETS):

1. Take one tablet (180mg) once daily with water.
2. Take on an empty stomach (at least 1 hour before or 2 hours after meals) for optimal absorption.
3. Avoid fruit juices (e.g., apple, orange, grapefruit)—they can reduce drug absorption by up to 40%.
4. Do not crush or chew—swallow whole.

When Not to Use (FEXET 180MG TABLETS):

Do not use if you have:

1. Hypersensitivity to fexofenadine or any excipients
2. Severe renal impairment (CrCl <30 mL/min)—dose adjustment required
3. Phenylketonuria (PKU)—check excipients for aspartame (rare in this strength)

Side Effects of (FEXET 180MG TABLETS):

Common: Headache, dizziness, mild nausea, fatigue, dry mouth.

Rare: Insomnia, menstrual discomfort, dyspepsia.

Serious (very rare): Hypersensitivity reactions (rash, angioedema), palpitations.

Fexofenadine is generally well-tolerated with no significant sedation or anticholinergic effects.

Dosage: (FEXET 180MG TABLETS):

1. Adults & adolescents (≥12 years): 180mg once daily for chronic urticaria or severe allergic rhinitis
2. Renal impairment (CrCl <30 mL/min): Reduce to 60mg once daily
3. Not recommended for children under 12 years (use age-appropriate formulations)

Who It’s For (FEXET 180MG TABLETS):

Adults and adolescents with chronic hives or severe seasonal allergies who require once-daily, high-potency, non-drowsy antihistamine therapy. Ideal for professionals, drivers, and students needing sustained alertness.

Warnings & Precautions:

1. Avoid co-administration with aluminum/magnesium-containing antacids within 2 hours (reduces absorption)
2. Use caution in elderly patients with reduced kidney function
3. Not a treatment for anaphylaxis—epinephrine is required in emergencies

Drug Interactions:

1. Antacids (Al/Mg hydroxide): ↓ Fexofenadine absorption—space doses by ≥2 hours
2. Fruit juices (apple, orange, grapefruit): ↓ Absorption—take with water only
3. Ketoconazole or erythromycin: May slightly increase fexofenadine levels (not clinically significant)
4. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date on the blister pack. Available over-the-counter in Pakistan.