Product Information:

FENOGET 200mg Capsules contain Fenofibrate as the active ingredient, a fibrate-class lipid-lowering agent. Fenofibrate works by activating peroxisome proliferator-activated receptor-alpha (PPAR-α), which increases lipoprotein lipase activity and reduces the production of apolipoprotein C-III. This leads to:

1. Significant reduction in triglycerides (TG)
2. Moderate increase in HDL ("good") cholesterol
3. Variable reduction in LDL ("bad") cholesterol (especially in hypertriglyceridemia)

FENOGET is used as an adjunct to diet in patients with primary hyperlipidemia or mixed dyslipidemia, particularly when triglycerides are elevated.

Uses of (FENOGET 200MG CAPSULES):

1. Severe hypertriglyceridemia (Fredrickson Type IV and V) to reduce risk of pancreatitis
2. Mixed dyslipidemia (elevated TG + low HDL ± elevated LDL)
3. Adjunct to statin therapy in high-risk cardiovascular patients with residual hypertriglyceridemia
4. Primary hypercholesterolemia (Fredrickson Type IIa/IIb) when statins are insufficient or not tolerated

Key Benefits of (FENOGET 200MG CAPSULES):

1. Lowers triglycerides by 30–50%
2. Raises HDL cholesterol by 10–20%
3. May reduce small dense LDL particles (more atherogenic)
4. Once-daily dosing for improved adherence
5. Available as a micronized formulation for better absorption

How To Use (FENOGET 200MG CAPSULES):

Take one capsule once daily, preferably with the main meal to enhance absorption. Swallow whole with water—do not crush or open. Continue a heart-healthy, low-fat diet and regular exercise. Use consistently at the same time each day.

When Not to Use (FENOGET 200MG CAPSULES):

Do not use if you have:

1. Severe renal impairment (eGFR <30 mL/min) or end-stage renal disease
2. Active liver disease or unexplained persistent elevations in liver enzymes
3. Gallbladder disease or history of cholelithiasis (gallstones)
4. Hypersensitivity to fenofibrate or any excipients
5. Pregnancy or breastfeeding

Side Effects of (FENOGET 200MG CAPSULES):

Common: Abdominal pain, nausea, diarrhea, headache, back pain, elevated liver enzymes.

Rare: Myalgia, rash, photosensitivity, gallstones.

Serious (rare):

1. Rhabdomyolysis (especially when combined with statins—symptoms: muscle pain, weakness, dark urine)
2. Pancreatitis (in severe hypertriglyceridemia despite treatment)
3. Liver injury (jaundice, fatigue, right upper quadrant pain)
4. Discontinue and seek medical help if muscle symptoms, dark urine, or jaundice occur.

Dosage: (FENOGET 200MG CAPSULES):

1. Standard adult dose: 200mg once daily with food
2. Renal impairment: Contraindicated if eGFR <30 mL/min; use lower dose (e.g., 145mg or 160mg) if eGFR 30–59 mL/min
3. Maximum effect: Seen within 2–4 weeks
4. Do not exceed recommended dose

Who It’s For (FENOGET 200MG CAPSULES):

Adults with high triglycerides, low HDL, or mixed dyslipidemia not controlled by diet or statins alone. Ideal for patients at risk of pancreatitis due to severe hypertriglyceridemia.

Warnings & Precautions:

1. Monitor liver function tests, lipid profile, and renal function before and during therapy
2. Avoid combining with statins unless clearly indicated—monitor for muscle toxicity
3. Discontinue if gallstones develop or liver enzymes rise significantly
4. May increase serum creatinine (usually reversible)—monitor kidney function

Drug Interactions:

1. Statins (e.g., simvastatin, atorvastatin): ↑ Risk of myopathy/rhabdomyolysis
2. Oral anticoagulants (e.g., warfarin): Fenofibrate may ↑ INR—monitor closely
3. Cyclosporine: ↑ Risk of nephrotoxicity and reduced cyclosporine efficacy
4. Bile acid sequestrants (e.g., cholestyramine): Administer 1 hour before or 4–6 hours after fenofibrate
5. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date on the blister pack. Available by prescription in Pakistan.