Product Information:

EZITA TAB 10mg Tablets contain Ezetimibe 10mg as the active ingredient. Ezetimibe is a cholesterol-lowering agent that works by inhibiting the absorption of dietary and biliary cholesterol in the small intestine, specifically by targeting the NPC1L1 transporter in the jejunal brush border. Unlike statins, it does not affect cholesterol synthesis. EZITA is used to lower elevated LDL ("bad") cholesterol levels and is often combined with statins for enhanced lipid control.

Uses of (EZITA TAB 10MG TABLETS):

1. Primary hypercholesterolemia (heterozygous familial and non-familial) as monotherapy or adjunct to statins
2. Homozygous familial hypercholesterolemia (as adjunct to other lipid-lowering treatments)
3. Mixed hyperlipidemia (Fredrickson Type IIa and IIb)
4. Adjunct to diet in patients with primary dyslipidemia
5. Reduction of cardiovascular risk in high-risk patients already on statin therapy

Key Benefits of (EZITA TAB 10MG TABLETS):

1. Reduces LDL cholesterol by 15–20% as monotherapy; up to 25% when added to statins
2. Neutral effect on HDL ("good") cholesterol and triglycerides
3. Well-tolerated with minimal systemic absorption
4. Once-daily dosing improves adherence
5. Can be used in statin-intolerant patients

How To Use (EZITA TAB 10MG TABLETS):

Take one tablet once daily, with or without food. Swallow whole with water—do not crush or chew. Continue a heart-healthy diet and exercise regimen. May be taken at the same time as a statin (e.g., atorvastatin, simvastatin) if prescribed together.

When Not to Use (EZITA TAB 10MG TABLETS):

Do not use if you have:

1. Hypersensitivity to ezetimibe or any excipients
2. Active liver disease or unexplained persistent elevations in liver enzymes
3. Pregnancy or breastfeeding (unless clearly needed and benefits outweigh risks)
4. Concomitant use with fibrates (except fenofibrate) due to limited safety data

Side Effects of (EZITA TAB 10MG TABLETS):

Common: Headache, diarrhea, abdominal pain, fatigue, nasopharyngitis.

Rare: Myalgia, elevated liver enzymes, hypersensitivity reactions (rash, angioedema).

Serious (very rare): Rhabdomyolysis (especially when combined with statins), hepatitis.

Discontinue and seek medical help if muscle pain, dark urine, or jaundice occurs.

Dosage: (EZITA TAB 10MG TABLETS):

1. Standard adult dose: 10mg once daily
2. No dose adjustment needed in renal impairment
3. Use with caution in moderate hepatic impairment; contraindicated in severe liver disease

Who It’s For (EZITA TAB 10MG TABLETS):

Adults with elevated LDL cholesterol who require additional lipid-lowering beyond diet or statin therapy. Ideal for statin-intolerant patients or those needing combination therapy for high cardiovascular risk.

Warnings & Precautions:

1. Monitor liver function tests before and during treatment if combined with statins
2. Report unexplained muscle pain, tenderness, or weakness immediately
3. Not a substitute for statins in high-risk cardiovascular patients unless indicated
4. Lifestyle modifications (diet, exercise) must accompany therapy

Drug Interactions:

1. Statins (e.g., simvastatin, atorvastatin): Safe combination; enhances LDL reduction
2. Cyclosporine: Increases ezetimibe levels—use with caution
3. Fibrates (except fenofibrate): Limited data; avoid unless necessary
4. Warfarin: Monitor INR—minor interaction possible
5. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date on the blister pack. Available by prescription in Pakistan.