Product Information:

EBAGET-D 10mg Tablets contain Ebastine 10mg and Desloratadine 5mg as active ingredients. This is a dual-antihistamine combination used for the symptomatic relief of allergic conditions.

1. Ebastine: A second-generation H1-antihistamine with rapid onset and long duration of action; minimally sedating.
2. Desloratadine: An active metabolite of loratadine, also a non-sedating antihistamine with anti-inflammatory properties that inhibits histamine, leukotrienes, and cytokines.

This combination provides enhanced relief in moderate to severe allergic rhinitis or chronic urticaria where monotherapy may be insufficient.

⚠️ Note: While dual antihistamine use is not first-line per international guidelines (due to limited added benefit and potential for increased side effects), this formulation is marketed in some regions like Pakistan for refractory allergy symptoms.

Uses of (EBAGET-D 10MG TABLETS):

1. Symptomatic treatment of seasonal and perennial allergic rhinitis (sneezing, runny nose, itchy eyes, nasal congestion)
2. Management of chronic idiopathic urticaria (hives) unresponsive to single antihistamine therapy
3. Relief from allergic conjunctivitis and pruritus (itching)

Key Benefits of (EBAGET-D 10MG TABLETS):

1. Dual blockade of histamine receptors for enhanced symptom control
2. Non-sedating profile (minimal CNS penetration)
3. Once-daily dosing for convenience
4. Anti-inflammatory effects beyond histamine blockade (desloratadine)

How To Use (EBAGET-D 10MG TABLETS):

Take one tablet once daily, with or without food. Swallow whole with water—do not crush or chew. Use only as needed or as prescribed for short-term control of severe allergy flares. Not intended for long-term daily use without medical supervision.

When Not to Use (EBAGET-D 10MG TABLETS):

Do not use if you have:

1. Hypersensitivity to ebastine, desloratadine, or any excipients
2. Severe hepatic impairment (both drugs are metabolized in the liver)
3. History of QT prolongation or arrhythmias (ebastine may rarely affect cardiac conduction at high doses)
4. Concomitant use of strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)—may increase ebastine levels

Side Effects of (EBAGET-D 10MG TABLETS):

Common: Headache, dry mouth, fatigue, mild drowsiness (despite "non-sedating" label), nausea.

Rare: Palpitations, insomnia, abdominal pain, elevated liver enzymes.

Serious (very rare): QT interval prolongation, hypersensitivity reactions.

Discontinue if cardiac symptoms (e.g., palpitations, dizziness) or severe rash occur.

Dosage: (EBAGET-D 10MG TABLETS):

1. Adults & adolescents (≥12 years): One tablet once daily
2. Maximum duration: Short-term use (≤7–10 days) unless directed by a physician
3. Not recommended for children under 12 years

Who It’s For (EBAGET-D 10MG TABLETS):

Adults and adolescents with severe or refractory allergic rhinitis or urticaria not controlled by standard antihistamines. Not for mild allergies or first-line use.

Warnings & Precautions:

1. Use cautiously in patients with liver disease
2. Avoid in elderly patients with cardiac risk factors
3. May cause drowsiness in sensitive individuals—avoid driving if affected
4. Not a substitute for epinephrine in anaphylaxis

Drug Interactions:

1. CYP3A4 inhibitors (ketoconazole, clarithromycin, grapefruit juice): May increase ebastine levels → risk of QT prolongation
2. CNS depressants (alcohol, benzodiazepines): Additive sedation (rare but possible)
3. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date on the blister pack. Available over-the-counter or by prescription in Pakistan.