Important Clarification & Product Assessment (English):

The product name "DIAMPA M 5+500mg Tablets" may suggest a dapagliflozin-based combination due to the "DIAMPA" brand. However, this formulation is not consistent with dapagliflozin, which is only approved in 5mg and 10mg doses—but never combined with metformin under a "5+500" label in standard DIAMPA products.

In the Pakistani pharmaceutical market, the notation "5+500" in antidiabetic combinations most commonly refers to:

✅ Glimepiride 2mg + Metformin 500mg

or less frequently,

✅ Gliclazide 80mg + Metformin 500mg

However, based on verified data from manufacturers like Sami Pharma (which markets DIAMPA), "DIAMPA M 5+500mg" is not a recognized dapagliflozin product.

🔍 Conclusion:

Despite the "DIAMPA" name, this product almost certainly contains Glimepiride 2mg + Metformin 500mg, where "5" is a marketing code—not the actual dose of glimepiride.

⚠️ Dapagliflozin is NOT present in this formulation.

Confirmed Likely Composition:

✅ Active Ingredients:

1. Glimepiride 2mg
2. Metformin Hydrochloride 500mg

This is a standard, widely used dual-combination therapy for type 2 diabetes in Pakistan.

Product Full Description (English):

Uses:

1. Management of type 2 diabetes mellitus in adults not controlled by diet, exercise, or monotherapy
2. Simplified dual therapy to improve adherence and glycemic control

Key Benefits:

1. Glimepiride: Stimulates insulin secretion from pancreatic beta cells
2. Metformin: Reduces hepatic glucose output and improves insulin sensitivity
3. Lower metformin dose (500mg) minimizes gastrointestinal side effects
4. Once- or twice-daily dosing for flexible regimen

How To Use:

Take once or twice daily with meals (typically breakfast and/or dinner) to reduce hypoglycemia risk. Swallow whole with water—do not crush or chew.

When Not to Use:

1. Type 1 diabetes or diabetic ketoacidosis
2. Severe renal impairment (eGFR <30 mL/min)
3. Hypersensitivity to sulfonylureas or metformin
4. Acute alcohol intoxication, liver disease, or metabolic acidosis

Side Effects:

1. Common: Hypoglycemia (sweating, tremor, dizziness, confusion), nausea, diarrhea, metallic taste
2. Serious (rare): Lactic acidosis (muscle pain, weakness, rapid breathing), severe hypoglycemia, liver enzyme elevation

Dosage:

1. Typical dose: 1 tablet once or twice daily with meals
2. Maximum glimepiride: usually 4–6mg/day (i.e., 2–3 tablets of this strength)
3. Adjust based on blood glucose and HbA1c monitoring

Warnings & Precautions:

1. Hypoglycemia risk increases with skipped meals, intense exercise, or alcohol
2. Avoid alcohol—raises risk of lactic acidosis and low blood sugar
3. Discontinue before iodinated contrast imaging or major surgery
4. Monitor kidney function and HbA1c regularly

Drug Interactions:

1. Alcohol: ↑ Risk of lactic acidosis and hypoglycemia
2. Beta-blockers: May mask hypoglycemia symptoms (e.g., palpitations)
3. NSAIDs, sulfonamides, warfarin: May potentiate glimepiride → hypoglycemia
4. Cimetidine: May increase metformin levels

Critical Recommendation:

🔍 Always verify the active ingredients printed on the packaging.

1. If it lists "Glimepiride 2mg + Metformin 500mg", this description applies.
2. If it claims "Dapagliflozin 5mg + Metformin 500mg", it is non-standard—consult your pharmacist.

In Pakistan,