Product Information:

DAPRODU 6mg Tablets contain Dapagliflozin 6mg, a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It works by inhibiting glucose reabsorption in the proximal renal tubules, leading to increased urinary excretion of glucose and a reduction in blood glucose levels in adults with type 2 diabetes mellitus.

⚠️ Critical Note:

The only globally approved and clinically validated dose of dapagliflozin is 10mg once daily (as per FDA, EMA, WHO, and major international guidelines). Dapagliflozin 6mg is not a standard or recognized strength in global pharmacopeias and is not available in most countries. This formulation appears to be a local variant marketed in Pakistan, possibly for dose titration or pricing segmentation. However, 6mg is considered subtherapeutic and may not deliver the full glycemic, cardiovascular, or renal benefits demonstrated in clinical trials.

Uses of (DAPRODU 6MG TAB):

1. Not approved as a standard therapy at this dose
2. May be used off-label under strict medical supervision in select cases (e.g., elderly patients, those prone to hypotension, or during initiation phase)
3. Standard indications for dapagliflozin (at 10mg) include:
4. Type 2 diabetes mellitus (as monotherapy or add-on)
5. Heart failure with reduced ejection fraction (HFrEF)—to reduce hospitalization and cardiovascular death
6. Chronic kidney disease (CKD) with albuminuria—to slow disease progression

❗ Recommendation: Confirm with your physician whether DAPRODU 10mg is appropriate. 6mg is unlikely to provide adequate HbA1c reduction or organ protection.

Key Benefits (Based on 10mg Data; Limited at 6mg):

1. Modest HbA1c reduction (likely <0.7% at 6mg vs. 0.8–1.0% at 10mg)
2. Mild weight loss and blood pressure reduction
3. Low risk of hypoglycemia when used alone

How To Use (DAPRODU 6MG TAB):

1. Take once daily in the morning, with or without food.
2. Swallow whole with water.
3. Do not substitute for 10mg in patients with heart failure or CKD unless specifically directed by a specialist.

When Not to Use:

1. Type 1 diabetes or diabetic ketoacidosis
2. Severe renal impairment (eGFR <30 mL/min)
3. History of necrotizing fasciitis of the perineum (Fournier’s gangrene)
4. Hypersensitivity to dapagliflozin

Side Effects (Lower Incidence at 6mg, But Still Possible):

Common:

1. Genital mycotic infections (e.g., vulvovaginal candidiasis, balanitis)
2. Urinary tract infections
3. Increased urination (polyuria)

Serious (rare):

1. Euglycemic diabetic ketoacidosis (nausea, vomiting, abdominal pain)—can occur even with normal blood sugar
2. Fournier’s gangrene (severe genital/periurethral pain, swelling, fever)—seek emergency care
3. Volume depletion (dizziness, hypotension)—especially in elderly or those on diuretics

Dosage:

1. Approved therapeutic dose: 10mg once daily
2. 6mg dose: Subtherapeutic—use only if explicitly prescribed and monitored

Who It’s For:

Adults with type 2 diabetes who may require a lower starting dose due to tolerability concerns—but only under close medical supervision.

Warnings & Precautions:

1. Monitor for signs of ketoacidosis during illness, surgery, or prolonged fasting
2. Maintain adequate hydration
3. Assess renal function before and during therapy
4. Discontinue temporarily before major surgical procedures

Drug Interactions:

1. Diuretics: May increase risk of dehydration and hypotension
2. Insulin or sulfonylureas: May slightly increase hypoglycemia risk
3. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.