Product Information:

DAPRODU 4mg Tablets contain Dapagliflozin 4mg, a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It lowers blood glucose by blocking glucose reabsorption in the kidneys, leading to increased urinary glucose excretion.

⚠️ Critical Note:

The only clinically approved and effective dose of dapagliflozin worldwide is 10mg once daily (per FDA, EMA, and global guidelines). Dapagliflozin 4mg is not a standard or recognized strength and is not available in international markets. This formulation appears to be a local product in Pakistan, likely intended for dose titration or cost-based segmentation, but it is subtherapeutic for approved indications.

While 4mg may offer mild glucose-lowering effects, it does not provide the full cardio-renal protective benefits established for the 10mg dose in large clinical trials (e.g., DECLARE-TIMI, DAPA-HF, DAPA-CKD).

Uses of (DAPRODU 4MG TAB):

1. Not approved as a standard therapy
2. May be used off-label in specific cases under strict medical supervision (e.g., elderly, hypotension-prone, or initiation-phase patients)
3. Standard indications for dapagliflozin (at 10mg) include:
4. Type 2 diabetes mellitus
5. Heart failure with reduced ejection fraction (HFrEF)
6. Chronic kidney disease (CKD) with albuminuria

❗ Recommendation: Confirm with your physician whether DAPRODU 10mg is appropriate. Do not assume 4mg provides equivalent benefit.

Key Benefits (Based on 10mg Data; Limited at 4mg):

1. Modest HbA1c reduction (likely <0.5% at 4mg)
2. Mild diuretic and blood pressure-lowering effect
3. Low risk of hypoglycemia (when not combined with insulin/sulfonylureas)

How To Use (DAPRODU 4MG TAB):

1. Take once daily in the morning, with or without food.
2. Swallow whole with water.
3. Not a substitute for 10mg in heart failure or CKD—use only if specifically prescribed at this dose.

When Not to Use:

1. Type 1 diabetes or diabetic ketoacidosis
2. eGFR <30 mL/min
3. History of Fournier’s gangrene
4. Hypersensitivity to dapagliflozin

Side Effects (Lower Risk at 4mg, But Still Possible):

Common:

1. Genital yeast infections
2. Urinary frequency

Serious (rare):

1. Euglycemic diabetic ketoacidosis
2. Fournier’s gangrene
3. Volume depletion (dizziness, especially in elderly)

Dosage:

1. Approved dose: 10mg once daily
2. 4mg: Subtherapeutic—use only under explicit medical guidance

Warnings & Precautions:

1. Monitor for signs of ketoacidosis during illness or surgery
2. Ensure adequate hydration
3. Renal function should be assessed before and during therapy

Drug Interactions:

1. Diuretics: ↑ risk of dehydration
2. Insulin/sulfonylureas: ↑ hypoglycemia risk (minimal with SGLT2i alone)

Additional Information:

Store below 30°C. Keep out of reach of children. Prescription-only in Pakistan.