Product Information:

DAPRODU 1mg Tablets contain Dapagliflozin 1mg, a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It works by blocking glucose reabsorption in the proximal renal tubules, leading to increased urinary glucose excretion and lowering of blood glucose levels in adults with type 2 diabetes mellitus.

⚠️ Important Note:

The standard approved dose of dapagliflozin is 10mg once daily. A 1mg strength is not commercially available globally and is not recognized in major pharmacopeias (e.g., FDA, EMA). This may represent a local formulation error, mislabeling, or an extremely low-dose experimental product. Dapagliflozin 1mg is not therapeutically effective for glycemic control.

Assuming this is a labeling variation or local naming convention, the following description is based on standard dapagliflozin pharmacology, with emphasis on safety due to the unusual strength.

Uses of (DAPRODU 1MG TAB):

1. Not indicated at 1mg dose for any approved condition
2. Standard dapagliflozin (10mg) is used for:
3. Type 2 diabetes mellitus (as monotherapy or add-on)
4. Heart failure with reduced ejection fraction (HFrEF)
5. Chronic kidney disease (CKD) with albuminuria

❗ Clarification: DAPRODU 1mg is unlikely to provide clinical benefit. Verify with your physician or pharmacist—this may be a labeling mistake (e.g., intended to be 10mg).

Key Benefits of (Standard Dapagliflozin 10mg):

1. Lowers HbA1c by 0.5–1.0%
2. Promotes modest weight loss and blood pressure reduction
3. Cardio- and renoprotective benefits independent of glucose control
4. Once-daily dosing

How To Use (If Confirmed as Dapagliflozin):

1. Take once daily in the morning, with or without food.
2. Swallow whole with water.
3. Standard dose: 10mg once daily—1mg is subtherapeutic.
4. Continue diet, exercise, and other antidiabetic medications as prescribed.

When Not to Use (DAPRODU 1MG TAB):

Do not use if you have:

1. Type 1 diabetes or diabetic ketoacidosis
2. Severe renal impairment (eGFR <30 mL/min)
3. History of necrotizing fasciitis of the perineum (Fournier’s gangrene)
4. Hypersensitivity to dapagliflozin

⚠️ Note: Even at 1mg, theoretical risks remain—though significantly reduced.

Side Effects (Theoretical at 1mg; More Relevant at 10mg):

Common (at therapeutic doses):

1. Genital mycotic infections (e.g., vulvovaginal candidiasis, balanitis)
2. Urinary tract infections
3. Increased urination (polyuria)

Serious (rare, but possible even at low doses):

1. Euglycemic diabetic ketoacidosis (symptoms: nausea, vomiting, abdominal pain, fatigue)—even with normal blood sugar
2. Fournier’s gangrene (severe genital/periurethral pain, fever, swelling)—medical emergency
3. Volume depletion (dizziness, hypotension)—especially in elderly or on diuretics

Dosage:

1. Approved dose: 10mg once daily
2. 1mg dose: Not clinically effective—likely a labeling or dispensing error

Who It’s For:

Adults with type 2 diabetes, HFrEF, or CKD—but only at 10mg dose.

Warnings & Precautions:

1. Monitor for signs of ketoacidosis, especially during illness or surgery
2. Maintain adequate hydration
3. Assess renal function before and during therapy
4. Discontinue before major surgery or prolonged fasting

Drug Interactions:

1. Diuretics: May increase risk of volume depletion
2. Insulin or sulfonylureas: May increase hypoglycemia risk (though SGLT2 inhibitors are low-risk alone)
3. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place. Keep out of reach of children. Do not use after expiration. Available by prescription in Pakistan.