Product Information:

COVAM PLUS 5/160/25mg Tablets is a triple-combination antihypertensive medication containing Amlodipine 5mg, Valsartan 160mg, and Hydrochlorothiazide 25mg. This formulation simultaneously targets three key mechanisms of blood pressure control:

1. Amlodipine: A calcium channel blocker that relaxes peripheral arteries, reducing vascular resistance.
2. Valsartan: An angiotensin II receptor blocker (ARB) that inhibits vasoconstriction and aldosterone-mediated fluid retention.
3. Hydrochlorothiazide: A thiazide diuretic at its standard maximum dose, promoting sodium and water excretion to reduce plasma volume.
4. This combination is designed for patients with moderate to severe hypertension uncontrolled on dual therapy, offering enhanced efficacy while using a lower dose of amlodipine to minimize side effects like edema.

Uses of (COVAM PLUS 5/160/25 TABLETS):

1. Treatment of essential hypertension in adults not adequately controlled with two antihypertensive agents
2. Intensification of therapy when dual combinations fail to achieve target blood pressure
3. Cardiovascular risk reduction in high-risk hypertensive patients requiring multi-drug regimens

Key Benefits of (COVAM PLUS 5/160/25 TABLETS):

1. Triple-mechanism action for superior blood pressure control
2. Lower amlodipine dose (5mg) reduces risk of peripheral edema
3. Once-daily dosing improves adherence and convenience
4. Reduces pill burden compared to taking three separate medications
5. Hydrochlorothiazide enhances the antihypertensive effect of both valsartan and amlodipine

How To Use (COVAM PLUS 5/160/25 TABLETS):

Take one tablet once daily in the morning, with or without food. Swallow whole with water—do not crush or chew. Take at the same time each day for consistent blood pressure control. Continue therapy even if you feel well, as hypertension is often asymptomatic. Do not discontinue without medical supervision.

When Not to Use (COVAM PLUS 5/160/25 TABLETS):

Do not use if you have:

1. Hypersensitivity to amlodipine, valsartan, hydrochlorothiazide, or sulfonamide-derived drugs
2. Pregnancy (especially second and third trimesters—risk of fetal injury or death)
3. Anuria or severe renal impairment (eGFR <30 mL/min)
4. Hepatic impairment, cholestasis, or biliary cirrhosis
5. Electrolyte imbalances (hypokalemia, hyponatremia, hypercalcemia)
6. History of gout (hydrochlorothiazide may elevate uric acid levels)
7. Concomitant use of aliskiren in diabetic patients

Side Effects of (COVAM PLUS 5/160/25 TABLETS):

Common: Dizziness, headache, mild ankle swelling, fatigue, increased urination, dry mouth, or flushing.

Serious (rare): Angioedema (swelling of face/lips/tongue), symptomatic hypotension, acute kidney injury, significant electrolyte disturbances (low potassium/sodium), hyperuricemia (gout flare), or cardiac arrhythmias due to hypokalemia. Seek immediate medical attention if breathing difficulty, fainting, irregular heartbeat, or muscle cramps occur.

Dosage: (COVAM PLUS 5/160/25 TABLETS):

1. Standard adult dose: One tablet once daily
2. Reserved for patients already stabilized on equivalent individual doses
3. Not intended for initial therapy or mild hypertension
4. Always follow your physician’s prescribed regimen.

Who It’s For (COVAM PLUS 5/160/25 TABLETS):

Adults with moderate to severe hypertension uncontrolled on dual therapy. Ideal for those needing intensified treatment with minimized amlodipine-related side effects. Not for children, pregnant women, or patients with significant renal/hepatic dysfunction.

Warnings & Precautions:

Monitor serum electrolytes (K⁺, Na⁺, Ca²⁺), renal function, uric acid, and blood pressure regularly. Avoid potassium supplements unless directed. Maintain adequate hydration—diarrhea, vomiting, or excessive sweating may cause dangerous imbalances. Use sunscreen due to photosensitivity from hydrochlorothiazide. Avoid in bilateral renal artery stenosis.

Drug Interactions:

1. Lithium: Hydrochlorothiazide may increase lithium levels → risk of toxicity
2. NSAIDs (e.g., ibuprofen, celecoxib): May reduce antihypertensive effect and impair kidney function
3. Simvastatin: Amlodipine may increase simvastatin exposure → myopathy risk
4. ACE inhibitors + Aliskiren: Triple blockade increases risk of renal failure and hyperkalemia
5. Always disclose all medications and supplements to your healthcare provider.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date printed on the blister pack. Available by prescription only in Pakistan.