It appears that the product name "COVAM PLUS /160/12.5 TABLETS" is missing the first component (likely Amlodipine) in the dose specification. Based on standard formulations of COVAM PLUS and similar triple-combination antihypertensives, this is most likely a typographical omission, and the intended product is:

COVAM PLUS 5/160/12.5mg TABLETS

(containing Amlodipine 5mg, Valsartan 160mg, and Hydrochlorothiazide 12.5mg)

Below is the complete product description for this corrected formulation:

Product Name:

COVAM PLUS 5/160/12.5MG TABLETS

Product Full Description (English):

Product Information:

COVAM PLUS 5/160/12.5mg Tablets is a triple-combination antihypertensive medication containing Amlodipine 5mg, Valsartan 160mg, and Hydrochlorothiazide 12.5mg. This formulation targets three complementary pathways in blood pressure regulation:

1. Amlodipine: A calcium channel blocker that relaxes arterial smooth muscle.
2. Valsartan: An angiotensin II receptor blocker (ARB) that inhibits vasoconstriction and aldosterone release.
3. Hydrochlorothiazide: A thiazide diuretic that reduces plasma volume by promoting sodium and water excretion.
4. This combination is designed for patients with moderate to severe hypertension uncontrolled on dual therapy, offering enhanced efficacy with a lower amlodipine dose to minimize side effects like edema.

Uses of (COVAM PLUS 5/160/12.5MG TABLETS):

1. Treatment of essential hypertension in adults not controlled with two antihypertensive agents
2. Step-up therapy from dual combinations (e.g., ARB + diuretic or CCB + ARB)
3. Cardiovascular risk reduction in high-risk hypertensive patients

Key Benefits of (COVAM PLUS 5/160/12.5MG TABLETS):

1. Triple-mechanism action for effective blood pressure control
2. Lower amlodipine dose (5mg) reduces risk of peripheral edema
3. Once-daily dosing improves adherence and convenience
4. Reduces pill burden compared to three separate medications
5. Valsartan counteracts fluid retention from amlodipine

How To Use (COVAM PLUS 5/160/12.5MG TABLETS):

Take one tablet once daily in the morning, with or without food. Swallow whole with water—do not crush or chew. Take at the same time each day. Continue even if you feel well. Do not stop without consulting your physician.

When Not to Use (COVAM PLUS 5/160/12.5MG TABLETS):

Do not use if you have:

1. Hypersensitivity to amlodipine, valsartan, hydrochlorothiazide, or sulfonamide-derived drugs
2. Pregnancy (especially second/third trimester—risk of fetal harm)
3. Severe renal impairment (eGFR <30 mL/min) or anuria
4. Hepatic impairment or cholestasis
5. Electrolyte imbalances (hypokalemia, hyponatremia, hypercalcemia)

Side Effects of (COVAM PLUS 5/160/12.5MG TABLETS):

Common: Dizziness, headache, mild ankle swelling, fatigue, increased urination.

Serious (rare): Angioedema, hypotension, acute kidney injury, electrolyte disturbances, or gout flare. Seek medical help if facial swelling, fainting, or irregular heartbeat occurs.

Dosage: (COVAM PLUS 5/160/12.5MG TABLETS):

1. Standard adult dose: One tablet once daily
2. Reserved for patients already controlled on equivalent individual doses
3. Not for initial hypertension treatment

Who It’s For (COVAM PLUS 5/160/12.5MG TABLETS):

Adults with uncontrolled hypertension on dual therapy, especially those sensitive to higher amlodipine doses. Not for children or pregnant women.

Warnings & Precautions:

Monitor electrolytes, renal function, and blood pressure regularly. Avoid potassium supplements. Use sunscreen (HCTZ causes photosensitivity). Stay hydrated.

Drug Interactions:

1. Lithium: ↑ Toxicity risk
2. NSAIDs: ↓ Antihypertensive effect
3. Simvastatin: ↑ Myopathy risk
4. Always disclose all medications to your doctor.

Additional Information:

Store below 30°C. Keep out of reach of children. Prescription-only in Pakistan.