Product Information:

COVAM PLUS 10/160/12.5mg Tablets is a triple-combination antihypertensive medication containing Amlodipine 10mg, Valsartan 160mg, and Hydrochlorothiazide 12.5mg. This formulation targets three key pathways in blood pressure regulation:

1. Amlodipine: A calcium channel blocker that relaxes arterial smooth muscle.
2. Valsartan: An angiotensin II receptor blocker (ARB) that inhibits vasoconstriction and aldosterone release.
3. Hydrochlorothiazide: A thiazide diuretic that reduces plasma volume by promoting sodium and water excretion.
4. This synergistic combination is designed for patients with moderate to severe hypertension uncontrolled on dual therapy.

Uses of (COVAM PLUS 10/160/12.5 TABLETS):

1. Treatment of essential hypertension in adults not adequately controlled with two antihypertensive agents
2. Intensification of therapy when dual combinations fail to achieve target blood pressure
3. Cardiovascular risk reduction in high-risk hypertensive patients

Key Benefits of (COVAM PLUS 10/160/12.5 TABLETS):

1. Triple-mechanism action for superior blood pressure control
2. Once-daily dosing improves adherence and convenience
3. Reduces pill burden compared to taking three separate medications
4. Minimizes peripheral edema (common with amlodipine monotherapy) via ARB counteraction
5. Proven efficacy in resistant hypertension

How To Use (COVAM PLUS 10/160/12.5 TABLETS):

Take one tablet once daily in the morning, with or without food. Swallow whole with water—do not crush or chew. Take at the same time each day. Continue even if you feel well, as hypertension is often asymptomatic. Do not stop without consulting your physician.

When Not to Use (COVAM PLUS 10/160/12.5 TABLETS):

Do not use if you have:

1. Hypersensitivity to amlodipine, valsartan, hydrochlorothiazide, or sulfonamide-derived drugs
2. Pregnancy (especially second/third trimester—risk of fetal toxicity)
3. Severe renal impairment (eGFR <30 mL/min) or anuria
4. Hepatic impairment or cholestasis
5. Hypokalemia, hyponatremia, hypercalcemia, or symptomatic hyperuricemia (gout)
6. Concomitant use of aliskiren in diabetic patients

Side Effects of (COVAM PLUS 10/160/12.5 TABLETS):

Common: Dizziness, headache, ankle swelling (mild), fatigue, increased urination, or flushing.

Serious (rare): Angioedema, acute kidney injury, significant electrolyte imbalances (low potassium/sodium), hypotension, hyperkalemia (from valsartan), or gout flare. Seek immediate medical help if facial swelling, severe dizziness, irregular heartbeat, or muscle weakness occurs.

Dosage: (COVAM PLUS 10/160/12.5 TABLETS):

1. Standard adult dose: One tablet once daily
2. Reserved for patients already stabilized on the individual components
3. Not for initial hypertension treatment or mild cases
4. Always follow your doctor’s instructions.

Who It’s For (COVAM PLUS 10/160/12.5 TABLETS):

Adults with resistant or uncontrolled hypertension despite dual therapy. Ideal for those requiring simplified regimen adherence. Not for children, pregnant women, or patients with severe organ dysfunction.

Warnings & Precautions:

Monitor serum electrolytes (K⁺, Na⁺), renal function, uric acid, and blood pressure regularly. Avoid potassium supplements unless directed. Stay hydrated—diarrhea, vomiting, or excessive sweating may cause dangerous imbalances. Use sunscreen due to photosensitivity from hydrochlorothiazide. Avoid in bilateral renal artery stenosis.

Drug Interactions:

1. Lithium: Hydrochlorothiazide ↑ lithium levels → toxicity
2. NSAIDs: May reduce antihypertensive effect and impair kidney function
3. Simvastatin: Amlodipine may ↑ simvastatin exposure → myopathy risk
4. ACE inhibitors + Aliskiren: Triple blockade ↑ risk of renal failure/hyperkalemia
5. Always disclose all medications to your healthcare provider.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date on the blister pack. Available by prescription only in Pakistan.