Product Information:

COVAM 5/80mg Tablets is a dual-combination antihypertensive medication containing Amlodipine 5mg and Valsartan 80mg. Amlodipine, a calcium channel blocker, relaxes blood vessels by inhibiting calcium entry into vascular smooth muscle cells. Valsartan, an angiotensin II receptor blocker (ARB), blocks the effects of angiotensin II, reducing vasoconstriction and aldosterone release. This combination provides complementary blood pressure control with a lower dose of both components, making it suitable for mild to moderate hypertension or as a starting combination therapy.

Uses of (COVAM 5/80MG TABLETS):

1. Treatment of essential hypertension in adults
2. Initial combination therapy in patients with stage 1–2 hypertension
3. Patients likely to require multiple drugs to achieve blood pressure goals
4. Alternative for those intolerant to ACE inhibitors due to dry cough

Key Benefits of (COVAM 5/80MG TABLETS):

1. Dual-mechanism action for enhanced efficacy over monotherapy
2. Lower doses minimize side effects (e.g., reduced risk of edema vs. higher amlodipine)
3. Once-daily dosing improves adherence
4. No dry cough (unlike ACE inhibitor combinations)
5. Valsartand helps counteract amlodipine-induced fluid retention

How To Use (COVAM 5/80MG TABLETS):

Take one tablet once daily at the same time each day, with or without food. Swallow whole with water—do not crush or chew. Continue even if you feel well, as high blood pressure often has no symptoms. Do not stop without consulting your doctor.

When Not to Use (COVAM 5/80MG TABLETS):

Do not use if you have:

1. Hypersensitivity to amlodipine, valsartan, or any excipients
2. Pregnancy (especially second and third trimesters—risk of fetal harm)
3. Severe hepatic impairment or biliary obstruction
4. Concomitant use of aliskiren in diabetic patients

Side Effects of (COVAM 5/80MG TABLETS):

Common: Dizziness, headache, flushing, mild ankle swelling, fatigue.

Serious (rare): Angioedema (swelling of face/lips/tongue), symptomatic hypotension, hyperkalemia, or acute kidney injury. Seek immediate medical help if breathing difficulty, severe dizziness, or facial swelling occurs.

Dosage: (COVAM 5/80MG TABLETS):

1. Standard adult dose: One tablet once daily
2. May be used as initial therapy or after inadequate response to monotherapy
3. Can be titrated to higher strengths (e.g., 5/160mg or 10/160mg) if needed
4. Always follow your physician’s prescribed regimen.

Who It’s For (COVAM 5/80MG TABLETS):

Adults with mild to moderate hypertension, especially those starting combination therapy or sensitive to higher drug doses. Not for children or pregnant women.

Warnings & Precautions:

Monitor renal function and serum potassium periodically, especially in elderly patients or those with heart/kidney disease. Avoid in bilateral renal artery stenosis. Dehydration may cause excessive hypotension—maintain adequate fluid intake.

Drug Interactions:

1. NSAIDs (e.g., ibuprofen): May reduce antihypertensive effect and impair kidney function
2. Potassium supplements or potassium-sparing diuretics: Risk of hyperkalemia
3. Simvastatin: Amlodipine may increase simvastatin levels → myopathy risk
4. Lithium: Valsartan may increase lithium levels—monitor closely
5. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date printed on the blister pack. Available by prescription in Pakistan.