Product Information:

COVAM 5/160mg Tablets is a dual-combination antihypertensive medication containing Amlodipine 5mg and Valsartan 160mg. Amlodipine, a calcium channel blocker, reduces peripheral vascular resistance by relaxing arterial smooth muscle. Valsartan, an angiotensin II receptor blocker (ARB), inhibits the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This combination provides synergistic blood pressure control with a lower dose of amlodipine to minimize side effects like edema.

Uses of (COVAM 5/160MG TABLETS):

1. Treatment of essential hypertension in adults not adequately controlled with monotherapy
2. Initial combination therapy in patients with high baseline blood pressure
3. Cardiovascular risk reduction in hypertensive patients requiring dual-pathway blockade

Key Benefits of (COVAM 5/160MG TABLETS):

1. Dual-mechanism action for effective 24-hour blood pressure control
2. Lower amlodipine dose (5mg) reduces risk of peripheral edema
3. Once-daily dosing improves treatment adherence
4. No dry cough (unlike ACE inhibitor-based regimens)
5. Valsartan counteracts fluid retention from amlodipine

How To Use (COVAM 5/160MG TABLETS):

Take one tablet once daily at the same time each day, with or without food. Swallow whole with water—do not crush or chew. Continue therapy even if you feel well, as hypertension is often asymptomatic. Do not discontinue without medical advice.

When Not to Use (COVAM 5/160MG TABLETS):

Do not use if you have:

1. Hypersensitivity to amlodipine, valsartan, or any excipients
2. Pregnancy (especially second and third trimesters—risk of fetal injury or death)
3. Severe hepatic impairment or biliary obstruction
4. Concomitant use of aliskiren in diabetic patients

Side Effects of (COVAM 5/160MG TABLETS):

Common: Dizziness, headache, flushing, mild ankle swelling, fatigue.

Serious (rare): Angioedema (swelling of face/lips/tongue), symptomatic hypotension, hyperkalemia, or acute kidney injury. Seek immediate medical help if breathing difficulty, severe dizziness, or facial swelling occurs.

Dosage: (COVAM 5/160MG TABLETS):

1. Standard adult dose: One tablet once daily
2. May be used as initial therapy in stage 2 hypertension or after inadequate response to monotherapy
3. Not recommended in elderly or volume-depleted patients without monitoring
4. Always follow your physician’s prescribed regimen.

Who It’s For (COVAM 5/160MG TABLETS):

Adults with mild to moderate hypertension requiring combination therapy. Ideal for those sensitive to higher amlodipine doses or at risk of edema. Not for children or pregnant women.

Warnings & Precautions:

Monitor renal function and serum potassium periodically. Avoid in bilateral renal artery stenosis. Dehydration (from diuretics, vomiting, or diarrhea) may cause excessive hypotension—maintain adequate fluid intake.

Drug Interactions:

1. NSAIDs (e.g., ibuprofen): May reduce antihypertensive effect and impair kidney function
2. Potassium supplements or potassium-sparing diuretics: Risk of hyperkalemia
3. Simvastatin: Amlodipine may increase simvastatin levels → myopathy risk
4. Lithium: Valsartan may increase lithium levels—monitor closely
5. Always disclose all medications to your healthcare provider.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date printed on the blister pack. Available by prescription in Pakistan.