Product Information:

COVAM 10/160mg Tablets is a dual-combination antihypertensive medication containing Amlodipine 10mg and Valsartan 160mg. Amlodipine, a calcium channel blocker, relaxes blood vessels by inhibiting calcium influx into vascular smooth muscle. Valsartan, an angiotensin II receptor blocker (ARB), blocks the vasoconstrictive and aldosterone-secreting effects of angiotensin II. Together, they provide synergistic blood pressure reduction with complementary mechanisms and improved tolerability.

Uses of (COVAM 10/160MG TABLETS):

1. Treatment of essential hypertension in adults not adequately controlled with monotherapy
2. Patients requiring combination therapy from the outset due to high baseline blood pressure
3. Cardiovascular risk reduction in hypertensive patients with compelling indications for both drug classes

Key Benefits of (COVAM 10/160MG TABLETS):

1. Dual-mechanism action for enhanced blood pressure control
2. Once-daily dosing improves adherence
3. Valsartan reduces amlodipine-induced peripheral edema
4. No risk of dry cough (unlike ACE inhibitor combinations)
5. Proven cardioprotective effects

How To Use (COVAM 10/160MG TABLETS):

Take one tablet once daily at the same time each day, with or without food. Swallow whole with water—do not crush or chew. Continue even if you feel well, as hypertension is often asymptomatic. Do not stop without consulting your physician.

When Not to Use (COVAM 10/160MG TABLETS):

Do not use if you have:

1. Hypersensitivity to amlodipine, valsartan, or any excipients
2. Pregnancy (especially second and third trimesters—risk of fetal harm)
3. Severe hepatic impairment or biliary obstruction
4. Concomitant use of aliskiren in diabetic patients

Side Effects of (COVAM 10/160MG TABLETS):

Common: Dizziness, headache, flushing, peripheral edema (ankle swelling), fatigue.

Serious (rare): Angioedema (swelling of face/lips/tongue), symptomatic hypotension, hyperkalemia, or acute kidney injury. Seek immediate medical help if breathing difficulty, severe dizziness, or facial swelling occurs.

Dosage: (COVAM 10/160MG TABLETS):

1. Standard adult dose: One tablet once daily
2. Typically used after inadequate response to either agent alone
3. Not recommended as initial therapy in elderly or volume-depleted patients
4. Always follow your physician’s prescribed regimen.

Who It’s For (COVAM 10/160MG TABLETS):

Adults with moderate to severe hypertension uncontrolled on single-agent therapy. Ideal for patients needing both vasodilation and RAAS blockade. Not for children or pregnant women.

Warnings & Precautions:

Monitor renal function and serum potassium periodically, especially in elderly patients or those with heart/kidney disease. Avoid in bilateral renal artery stenosis. Dehydration may cause excessive hypotension—ensure adequate fluid intake.

Drug Interactions:

1. NSAIDs (e.g., ibuprofen): May reduce antihypertensive effect and impair kidney function
2. Potassium supplements or potassium-sparing diuretics: Risk of hyperkalemia
3. Simvastatin: Amlodipine may increase simvastatin levels → myopathy risk
4. Lithium: Valsartan may increase lithium levels—monitor closely
5. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date printed on the blister pack. Available by prescription in Pakistan.