Product Information:

COVA-H 80/12.5mg Tablets is a fixed-dose combination antihypertensive medication containing Valsartan 80mg and Hydrochlorothiazide 12.5mg. Valsartan, an angiotensin II receptor blocker (ARB), relaxes blood vessels by blocking the action of angiotensin II, while Hydrochlorothiazide, a thiazide diuretic, reduces blood volume by increasing the excretion of sodium and water through the kidneys. This dual-action formulation provides enhanced blood pressure control in patients who do not achieve target levels with monotherapy.

Uses of (COVA-H 80/12.5MG TABLETS):

1. Treatment of essential hypertension (high blood pressure) in adults
2. Patients inadequately controlled on either valsartan or hydrochlorothiazide alone
3. Step-down therapy after higher-dose combination treatment
4. Cardiovascular risk reduction in hypertensive individuals requiring dual therapy

Key Benefits of (COVA-H 80/12.5MG TABLETS):

1. Lower-strength combination ideal for mild to moderate hypertension
2. Once-daily dosing improves adherence
3. Reduced risk of dry cough compared to ACE inhibitor-based regimens
4. Hydrochlorothiazide helps counteract fluid retention
5. Proven efficacy with improved tolerability over high-dose monotherapy

How To Use (COVA-H 80/12.5MG TABLETS):

Take one tablet once daily in the morning, with or without food. Swallow whole with water—do not crush or chew. Take at the same time each day for consistent blood pressure control. Continue therapy even if you feel well, as hypertension is often asymptomatic. Do not discontinue without medical advice.

When Not to Use (COVA-H 80/12.5MG TABLETS):

Do not use if you have:

1. Hypersensitivity to valsartan, hydrochlorothiazide, or sulfonamide-derived drugs
2. Anuria (absence of urine production) or severe renal impairment
3. Hepatic dysfunction or cholestasis
4. Pregnancy (especially second and third trimesters—can cause fetal injury or death)
5. Electrolyte imbalances (e.g., hypokalemia, hyponatremia, hypercalcemia)

Side Effects of (COVA-H 80/12.5MG TABLETS):

Common: Dizziness, headache, fatigue, increased urination, mild dehydration, or low potassium levels.

Serious (rare): Angioedema (swelling of face/lips/tongue), acute kidney injury, electrolyte disturbances, hyperuricemia (gout flare), or symptomatic hypotension. Seek immediate medical attention if breathing difficulty, severe dizziness, irregular heartbeat, or muscle cramps occur.

Dosage: (COVA-H 80/12.5MG TABLETS):

1. Standard adult dose: One tablet once daily
2. May be escalated to COVA-H 160/12.5mg or 160/25mg based on response
3. Not intended as initial monotherapy—typically used after inadequate response to single-agent treatment
4. Always follow your physician’s prescribed regimen.

Who It’s For (COVA-H 80/12.5MG TABLETS):

Adults with mild to moderate hypertension requiring combination therapy. Ideal for elderly patients or those sensitive to higher drug doses. Not for children, pregnant women, or individuals with severe kidney or liver disease.

Warnings & Precautions:

Monitor serum electrolytes (potassium, sodium), renal function, and uric acid periodically. Avoid potassium supplements unless directed. Stay well-hydrated—excessive sweating, vomiting, or diarrhea may worsen electrolyte imbalance. Use sunscreen, as hydrochlorothiazide increases photosensitivity.

Drug Interactions:

1. Lithium: Hydrochlorothiazide may increase lithium levels → toxicity risk
2. NSAIDs (e.g., ibuprofen): May reduce antihypertensive effect and impair kidney function
3. ACE inhibitors or potassium-sparing diuretics: Risk of hyperkalemia or renal dysfunction
4. Antidiabetic medications: Thiazides may alter glucose control
5. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date printed on the blister pack. Available by prescription in Pakistan.