Product Information:

COVA-H 160/12.5mg Tablets is a fixed-dose combination antihypertensive medication containing Valsartan 160mg and Hydrochlorothiazide 12.5mg. Valsartan is an angiotensin II receptor blocker (ARB) that relaxes blood vessels, while Hydrochlorothiazide is a thiazide diuretic that reduces blood volume by promoting sodium and water excretion. Together, they provide synergistic blood pressure control in patients not adequately managed with monotherapy.

Uses of (COVA-H 160/12.5MG TABLETS):

1. Treatment of essential hypertension (high blood pressure) in adults
2. Patients whose blood pressure is not controlled with valsartan or hydrochlorothiazide alone
3. Reduction of cardiovascular risk in hypertensive patients requiring combination therapy

Key Benefits of (COVA-H 160/12.5MG TABLETS):

1. Dual mechanism for enhanced blood pressure reduction
2. Once-daily dosing improves treatment adherence
3. Lower risk of dry cough compared to ACE inhibitor-based combinations
4. Hydrochlorothiazide counters fluid retention sometimes seen with ARBs
5. Proven cardiovascular and renal protective effects

How To Use (COVA-H 160/12.5MG TABLETS):

Take one tablet once daily, preferably in the morning, with or without food. Swallow whole with water—do not crush or chew. Take at the same time each day. Continue even if you feel well, as hypertension often has no symptoms. Do not stop without consulting your doctor.

When Not to Use (COVA-H 160/12.5MG TABLETS):

Do not use if you have:

1. Hypersensitivity to valsartan, hydrochlorothiazide, or sulfonamide-derived drugs
2. Anuria (inability to produce urine) or severe renal impairment
3. Hepatic impairment or cholestasis
4. Pregnancy (especially second and third trimesters—risk of fetal harm)
5. Hypokalemia, hyponatremia, or hypercalcemia
6. Concomitant use of aliskiren in diabetic patients

Side Effects of (COVA-H 160/12.5MG TABLETS):

Common: Dizziness, headache, fatigue, low potassium (hypokalemia), increased urination, or mild dehydration.

Serious (rare): Angioedema, acute kidney injury, electrolyte imbalances (low sodium, high calcium), hyperuricemia (gout flare), or symptomatic hypotension. Seek medical help if swelling of face/lips, severe dizziness, irregular heartbeat, or muscle weakness occurs.

Dosage: (COVA-H 160/12.5MG TABLETS):

1. Standard adult dose: One tablet once daily
2. May be titrated to higher strengths (e.g., 320/25mg) if needed
3. Not recommended as initial therapy—usually started after monotherapy failure
4. Always follow your physician’s instructions.

Who It’s For (COVA-H 160/12.5MG TABLETS):

Adults with moderate to severe hypertension uncontrolled on single-agent therapy. Ideal for patients needing both vasodilation and fluid management. Not for children, pregnant women, or those with severe kidney/liver disease.

Warnings & Precautions:

Monitor serum potassium, sodium, creatinine, and uric acid periodically. Avoid potassium supplements unless directed. Stay hydrated—excessive sweating, vomiting, or diarrhea may cause dangerous electrolyte shifts. Use sunscreen—hydrochlorothiazide increases photosensitivity.

Drug Interactions:

1. Lithium: Hydrochlorothiazide may increase lithium toxicity
2. NSAIDs: May reduce antihypertensive effect and impair kidney function
3. Potassium-sparing diuretics or ACE inhibitors: Risk of hyperkalemia or renal impairment
4. Antidiabetic drugs: Thiazides may alter glucose control
5. Always disclose all medications to your doctor.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date on the blister pack. Available by prescription in Pakistan.