Product Information:

COTASMI 80mg Tablets contain Montelukast Sodium as the active ingredient, a potent leukotriene receptor antagonist that selectively blocks cysteinyl leukotriene receptors in the airways and other tissues. Leukotrienes are inflammatory mediators that cause bronchoconstriction, mucus hypersecretion, and vascular leakage in asthma and allergic conditions. By inhibiting their action, montelukast reduces inflammation and improves respiratory function. The 80mg strength is specifically formulated for adolescents and adults requiring higher-dose therapy.

Uses of (COTASMI 80MG TABLETS):

1. Chronic management of mild to moderate persistent asthma
2. Prevention of exercise-induced bronchoconstriction
3. Symptomatic relief of seasonal and perennial allergic rhinitis
4. Adjunctive therapy in patients with coexisting asthma and allergies

Key Benefits of (COTASMI 80MG TABLETS):

1. Once-daily dosing for sustained 24-hour control
2. Non-steroidal anti-inflammatory action with minimal systemic effects
3. Reduces nighttime asthma symptoms and improves sleep quality
4. Enhances lung function and decreases rescue inhaler use
5. Safe for long-term maintenance therapy

How To Use (COTASMI 80MG TABLETS):

Take one tablet once daily in the evening, with or without food. Swallow whole with water—do not crush or chew. For asthma, take regularly even when asymptomatic. For allergic rhinitis, evening dosing is preferred if used for both conditions. Not for acute asthma attacks—always carry a fast-acting bronchodilator (e.g., salbutamol).

When Not to Use (COTASMI 80MG TABLETS):

Do not use if you have hypersensitivity to montelukast or any excipients. Avoid as monotherapy in severe asthma. Not indicated for acute bronchospasm or status asthmaticus. Use cautiously in patients with psychiatric history due to risk of neuropsychiatric events.

Side Effects of (COTASMI 80MG TABLETS):

Common: Headache, abdominal pain, heartburn, fatigue, or upper respiratory infection.

Serious (rare): Neuropsychiatric effects (e.g., depression, anxiety, agitation, suicidal ideation, sleep disturbances), hypersensitivity reactions (rash, eosinophilia), or elevated liver enzymes. Discontinue and seek medical help if mood changes, hallucinations, or severe skin reactions occur.

Dosage: (COTASMI 80MG TABLETS):

1. Adults & adolescents (≥15 years): One 80mg tablet once daily in the evening
2. Not approved for children under 15 years (use 4mg or 5mg formulations instead)
3. Maximum therapeutic effect may take several days of consistent use

Who It’s For (COTASMI 80MG TABLETS):

Adults and adolescents aged 15 years and older with persistent asthma or significant allergic rhinitis requiring robust leukotriene blockade. Ideal for patients on combination therapy or those intolerant to inhaled corticosteroids.

Warnings & Precautions:

Montelukast carries regulatory warnings for neuropsychiatric side effects. Monitor closely for new or worsening depression, anxiety, aggression, or behavioral changes. Do not substitute for rescue medication during acute episodes. Inform your doctor if you have a history of mental health disorders.

Drug Interactions:

1. Rifampin, phenobarbital: May reduce montelukast levels (CYP3A4/2C8 induction)
2. Gemfibrozil: May increase montelukast exposure
3. No clinically significant interactions with inhaled corticosteroids, antihistamines, or short-acting beta-agonists
4. Always disclose all medications to your healthcare provider.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date printed on the blister pack. Available by prescription in Pakistan.