Product Information:

COTASMI 40mg Tablets contain Montelukast Sodium as the active ingredient, a selective leukotriene receptor antagonist that blocks the action of cysteinyl leukotrienes—potent inflammatory mediators involved in asthma and allergic rhinitis. By inhibiting leukotriene receptors in the airways, it reduces bronchoconstriction, mucus secretion, and vascular permeability, thereby improving respiratory function and alleviating allergy symptoms.

Uses of (COTASMI 40MG TABLETS):

1. Prophylaxis and chronic treatment of asthma in adults and adolescents
2. Prevention of exercise-induced bronchoconstriction
3. Relief of symptoms of seasonal and perennial allergic rhinitis (e.g., sneezing, nasal congestion, runny nose, itchy eyes)

Key Benefits of (COTASMI 40MG TABLETS):

1. Once-daily dosing for 24-hour symptom control
2. Non-steroidal mechanism with minimal systemic side effects
3. Effective in both asthma and allergic rhinitis
4. Improves lung function and reduces nighttime symptoms
5. Can be used alongside inhaled corticosteroids or antihistamines

How To Use (COTASMI 40MG TABLETS):

Take one tablet once daily in the evening, with or without food. Swallow whole with water—do not crush or chew. For asthma, take regularly even when asymptomatic. For allergic rhinitis, may be taken at any time of day, but evening dosing is preferred if used for both conditions. Do not use for acute asthma attacks.

When Not to Use (COTASMI 40MG TABLETS):

Do not use if you have known hypersensitivity to montelukast or any excipients. Not intended for acute bronchospasm or status asthmaticus. Use with caution in patients with psychiatric disorders due to risk of neuropsychiatric events.

Side Effects of (COTASMI 40MG TABLETS):

Common: Headache, abdominal pain, diarrhea, nausea, or mild fatigue.

Serious (rare): Neuropsychiatric events (e.g., agitation, depression, anxiety, suicidal thoughts, sleep disturbances), hypersensitivity reactions, or elevated liver enzymes. Discontinue and seek medical help if mood changes, hallucinations, or severe rash occur.

Dosage: (COTASMI 40MG TABLETS):

1. Adults & adolescents (≥15 years): One 40mg tablet once daily in the evening
2. Not recommended for children under 15 years (use age-appropriate strengths like 4mg or 5mg)
3. Maximum effect may take several days of consistent use

Who It’s For (COTASMI 40MG TABLETS):

Adults and adolescents aged 15 years and older with persistent asthma or moderate to severe allergic rhinitis. Ideal for patients requiring add-on therapy to inhaled corticosteroids or seeking non-sedating allergy relief.

Warnings & Precautions:

Montelukast carries FDA/EMA warnings for neuropsychiatric side effects. Monitor for new or worsening depression, anxiety, or behavioral changes. Do not substitute for rescue inhalers during acute asthma episodes. Inform your doctor if you have a history of mental health conditions.

Drug Interactions:

1. Phenobarbital, rifampin: May reduce montelukast levels (enzyme induction)
2. Gemfibrozil: May increase montelukast exposure
3. No significant interaction with most antihistamines, corticosteroids, or bronchodilators
4. Always disclose all medications to your physician.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date on the blister pack. Available by prescription in Pakistan.